{"entity": "researcher", "timestamp": "2026-08-20T20:40:53.473Z", "family": "Michel", "given": "Maurice", "initials": "M", "orcid": "0000-0003-3261-2493", "affiliations": ["Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.", "Center for Molecular Medicine, Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f4696e361fe4aa3823d263674d1a498.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f4696e361fe4aa3823d263674d1a498"}}, "publications": [{"entity": "publication", "iuid": "0b2836a6ff6d4195b7fd93c3dc724164", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0b2836a6ff6d4195b7fd93c3dc724164.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0b2836a6ff6d4195b7fd93c3dc724164"}}, "title": "Organocatalytic Switches of DNA Glycosylase OGG1 Catalyze a Highly Efficient AP-Lyase Function.", "authors": [{"family": "Kehler", "given": "Mario", "initials": "M"}, {"family": "Zhou", "given": "Kaixin", "initials": "K"}, {"family": "Kemas", "given": "Aurino M", "initials": "AM"}, {"family": "Del Prado", "given": "Alicia", "initials": "A"}, {"family": "Hutchinson", "given": "Emma Scaletti", "initials": "ES"}, {"family": "Nairn", "given": "Elinor Hesslefors", "initials": "EH"}, {"family": "Varga", "given": "Marek", "initials": "M"}, {"family": "Plattner", "given": "Yvonne", "initials": "Y"}, {"family": "Zhong", "given": "Yi", "initials": "Y"}, {"family": "Purewal-Sidhu", "given": "Oryn", "initials": "O"}, {"family": "Haslam", "given": "James", "initials": "J"}, {"family": "Wiita", "given": "Elis\u00e9e", "initials": "E"}, {"family": "Gildie", "given": "Heather", "initials": "H"}, {"family": "Singerova", "given": "Karolina", "initials": "K"}, {"family": "Szaruga", "given": "Zuzanna", "initials": "Z"}, {"family": "Alml\u00f6f", "given": "Ingrid", "initials": "I"}, {"family": "Hormann", "given": "Femke M", "initials": "FM"}, {"family": "Liu", "given": "Kang-Cheng", "initials": "KC"}, {"family": "Wallner", "given": "Olov", "initials": "O"}, {"family": "Ortis", "given": "Florian", "initials": "F"}, {"family": "Homan", "given": "Evert J", "initials": "EJ"}, {"family": "Gileadi", "given": "Opher", "initials": "O"}, {"family": "Rudd", "given": "Sean G", "initials": "SG"}, {"family": "Stenmark", "given": "P\u00e5l", "initials": "P"}, {"family": "de Vega", "given": "Miguel", "initials": "M"}, {"family": "Helleday", "given": "Thomas", "initials": "T"}, {"family": "D'Arcy-Evans", "given": "Nicholas D", "initials": "ND"}, {"family": "Lauschke", "given": "Volker M", "initials": "VM"}, {"family": "Michel", "given": "Maurice", "initials": "M", "orcid": "0000-0003-3261-2493", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f4696e361fe4aa3823d263674d1a498.json"}}], "type": "journal article", "published": "2025-06-12", "journal": {"title": "Chemistry", "issn": "1521-3765", "volume": "31", "issue": "33", "pages": "e202500382", "issn-l": "0947-6539"}, "abstract": "8-oxoGuanine DNA glycosylase 1 (OGG1) is the first known target of organocatalytic switches (ORCAs), which rewrite the biochemical function of the enzyme through redirection of its preferred substrate from 8-oxoG to AP sites. Previously, different ORCA chemotypes were shown to enhance the operational pH window for OGG1, possibly through direct involvement in proton transfer events during DNA strand cleavage. Accordingly, compound pKa is a crucial and necessary consideration for the identification and application of future OGG1 ORCAs. Here, we identify a minimal structure of organocatalytic switches-4-anilino pyridines and 6-anilino pyrimidines-which are dimethyl-amino-pyridine (DMAP)-type Br\u00f8nsted bases binding the active site of OGG1. Systematic interrogation of compound basicity through modulation of electron-withdrawing (EWG) and electron-donating (EDG) substituents reveals that a pKa less or equal to the assay pH is a viable parameter for prediction of compound activity. The lead structure (AC50 13 nM, pKa 7.0) was then identified as a potent scaffold from a screen in a patient-derived 3D model of metabolic dysfunction-associated steatohepatitis (MASH), where it reduced hepatic fibrosis by 35%. Collectively, these findings deepen the knowledge of this novel modulator class, with important implications for future enzyme targets and probe development.", "doi": "10.1002/chem.202500382", "pmid": "40294343", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12160960"}], "notes": [], "created": "2026-08-20T06:31:12.116Z", "modified": "2026-08-20T06:31:12.196Z"}, {"entity": "publication", "iuid": "60632dadc0ab4927a77a984095ddc8d8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/60632dadc0ab4927a77a984095ddc8d8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/60632dadc0ab4927a77a984095ddc8d8"}}, "title": "Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1", "authors": [{"family": "Hank", "given": "Emily C", "initials": "EC", "orcid": "0000-0002-3777-4697", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2b412977f2364bef9ec63aa5e552331a.json"}}, {"family": "D'Arcy-Evans", "given": "Nicholas", "initials": "N"}, {"family": "Scaletti", "given": "Emma Rose", "initials": "ER"}, {"family": "Ben\u00edtez-Buelga", "given": "Carlos", "initials": "C"}, {"family": "Wallner", "given": "Olov", "initials": "O", "orcid": "0000-0002-6481-237X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3601a5a4d88f4452b6d1ac5f22c79d9f.json"}}, {"family": "Ortis", "given": "Florian", "initials": "F"}, {"family": "Zhou", "given": "Kaixin", "initials": "K"}, {"family": "Meng", "given": "Liuzhen", "initials": "L"}, {"family": "Calvo", "given": "Patricia", "initials": "P"}, {"family": "Alml\u00f6f", "given": "Ingrid", "initials": "I"}, {"family": "Wiita", "given": "Elis\u00e9e", "initials": "E"}, {"family": "Kosenina", "given": "Sara", "initials": "S"}, {"family": "Kr\u00e4mer", "given": "Andreas", "initials": "A"}, {"family": "Long", "given": "Maeve", "initials": "M"}, {"family": "Jemth", "given": "Ann Sofie", "initials": "AS"}, {"family": "Dawson", "given": "Holly", "initials": "H"}, {"family": "Stewart", "given": "Josephine", "initials": "J"}, {"family": "Dickey", "given": "Adam", "initials": "A"}, {"family": "Astorga", "given": "Mikhael E", "initials": "ME"}, {"family": "Varga", "given": "Marek", "initials": "M"}, {"family": "Homan", "given": "Evert J", "initials": "EJ"}, {"family": "Scobie", "given": "Martin", "initials": "M", "orcid": "0000-0002-7073-8495", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bdce0df415d54e9d84a4fcbb4d1350e5.json"}}, {"family": "Knapp", "given": "Stefan", "initials": "S", "orcid": "0000-0001-5995-6494", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6025ceada8d460aa28aa3175e423853.json"}}, {"family": "de Vega", "given": "Miguel", "initials": "M"}, {"family": "Sastre", "given": "Leandro", "initials": "L"}, {"family": "Stenmark", "given": "P\u00e5l", "initials": "P"}, {"family": "Helleday", "given": "Thomas", "initials": "T"}, {"family": "Michel", "given": "Maurice", "initials": "M", "orcid": "0000-0003-3261-2493", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f4696e361fe4aa3823d263674d1a498.json"}}], "type": "posted-content", "published": "2025-01-01", "journal": {"issn-l": null}, "abstract": null, "doi": "10.26434/chemrxiv-2023-70gws-v4", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:03:18.157Z", "modified": "2026-08-20T13:03:18.195Z"}, {"entity": "publication", "iuid": "b16547b43d764b1395c221acf753aa06", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b16547b43d764b1395c221acf753aa06.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b16547b43d764b1395c221acf753aa06"}}, "title": "Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1", "authors": [{"family": "Hank", "given": "Emily C", "initials": "EC", "orcid": "0000-0002-3777-4697", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2b412977f2364bef9ec63aa5e552331a.json"}}, {"family": "D'Arcy-Evans", "given": "Nicholas", "initials": "N"}, {"family": "Scaletti", "given": "Emma Rose", "initials": "ER"}, {"family": "Ben\u00edtez-Buelga", "given": "Carlos", "initials": "C"}, {"family": "Wallner", "given": "Olov", "initials": "O", "orcid": "0000-0002-6481-237X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3601a5a4d88f4452b6d1ac5f22c79d9f.json"}}, {"family": "Ortis", "given": "Florian", "initials": "F"}, {"family": "Zhou", "given": "Kaixin", "initials": "K"}, {"family": "Meng", "given": "Liuzhen", "initials": "L"}, {"family": "Calvo", "given": "Patricia", "initials": "P"}, {"family": "Alml\u00f6f", "given": "Ingrid", "initials": "I"}, {"family": "Wiita", "given": "Elis\u00e9e", "initials": "E"}, {"family": "Kosenina", "given": "Sara", "initials": "S"}, {"family": "Kr\u00e4mer", "given": "Andreas", "initials": "A"}, {"family": "Long", "given": "Maeve", "initials": "M"}, {"family": "Jemth", "given": "Ann Sofie", "initials": "AS"}, {"family": "Dawson", "given": "Holly", "initials": "H"}, {"family": "Stewart", "given": "Josephine", "initials": "J"}, {"family": "Dickey", "given": "Adam", "initials": "A"}, {"family": "Astorga", "given": "Mikhael E", "initials": "ME"}, {"family": "Varga", "given": "Marek", "initials": "M"}, {"family": "Homan", "given": "Evert J", "initials": "EJ"}, {"family": "Scobie", "given": "Martin", "initials": "M", "orcid": "0000-0002-7073-8495", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bdce0df415d54e9d84a4fcbb4d1350e5.json"}}, {"family": "Knapp", "given": "Stefan", "initials": "S", "orcid": "0000-0001-5995-6494", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6025ceada8d460aa28aa3175e423853.json"}}, {"family": "de Vega", "given": "Miguel", "initials": "M"}, {"family": "Sastre", "given": "Leandro", "initials": "L"}, {"family": "Stenmark", "given": "P\u00e5l", "initials": "P"}, {"family": "Helleday", "given": "Thomas", "initials": "T"}, {"family": "Michel", "given": "Maurice", "initials": "M", "orcid": "0000-0003-3261-2493", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f4696e361fe4aa3823d263674d1a498.json"}}], "type": "posted-content", "published": "2024-05-10", "journal": {"issn-l": null}, "abstract": null, "doi": "10.26434/chemrxiv-2023-70gws-v3", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:03:16.365Z", "modified": "2026-08-20T13:03:16.442Z"}, {"entity": "publication", "iuid": "2a68fd9398404681ac972af93479c615", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2a68fd9398404681ac972af93479c615.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2a68fd9398404681ac972af93479c615"}}, "title": "Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1", "authors": [{"family": "Hank", "given": "Emily C", "initials": "EC", "orcid": "0000-0002-3777-4697", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2b412977f2364bef9ec63aa5e552331a.json"}}, {"family": "D'Arcy-Evans", "given": "Nicholas", "initials": "N"}, {"family": "Wallner", "given": "Olov", "initials": "O", "orcid": "0000-0002-6481-237X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3601a5a4d88f4452b6d1ac5f22c79d9f.json"}}, {"family": "Ortis", "given": "Florian", "initials": "F"}, {"family": "Meng", "given": "Liuzhen", "initials": "L"}, {"family": "Calvo", "given": "Patricia", "initials": "P"}, {"family": "Scaletti", "given": "Emma Rose", "initials": "ER"}, {"family": "Kosenina", "given": "Sara", "initials": "S"}, {"family": "Dawson", "given": "Holly", "initials": "H"}, {"family": "Stewart", "given": "Josephine", "initials": "J"}, {"family": "Dickey", "given": "Adam", "initials": "A"}, {"family": "Astorga", "given": "Mikhael E", "initials": "ME"}, {"family": "Wiita", "given": "Elis\u00e9e", "initials": "E"}, {"family": "Varga", "given": "Marek", "initials": "M"}, {"family": "Homan", "given": "Evert J", "initials": "EJ"}, {"family": "Jemth", "given": "Ann Sofie", "initials": "AS"}, {"family": "Ben\u00edtez-Buelga", "given": "Carlos", "initials": "C"}, {"family": "Scobie", "given": "Martin", "initials": "M", "orcid": "0000-0002-7073-8495", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bdce0df415d54e9d84a4fcbb4d1350e5.json"}}, {"family": "Helleday", "given": "Thomas", "initials": "T"}, {"family": "Stenmark", "given": "P\u00e5l", "initials": "P"}, {"family": "de Vega", "given": "Miguel", "initials": "M"}, {"family": "Michel", "given": "Maurice", "initials": "M", "orcid": "0000-0003-3261-2493", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f4696e361fe4aa3823d263674d1a498.json"}}], "type": "posted-content", "published": "2023-07-26", "journal": {"issn-l": null}, "abstract": null, "doi": "10.26434/chemrxiv-2023-70gws", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:03:14.392Z", "modified": "2026-08-20T13:03:14.451Z"}, {"entity": "publication", "iuid": "aff3deb699254064b0771cb94411adfb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/aff3deb699254064b0771cb94411adfb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/aff3deb699254064b0771cb94411adfb"}}, "title": "Front Cover: Optimization of \u2010Piperidinyl\u2010Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8\u2010Oxo\u2010Guanine DNA Glycosylase 1 (ChemMedChem 1/2023)", "authors": [{"family": "Wallner", "given": "Olov", "initials": "O"}, {"family": "C\u00e1zares\u2010K\u00f6rner", "given": "Armando", "initials": "A"}, {"family": "Scaletti", "given": "Emma Rose", "initials": "ER"}, {"family": "Masuyer", "given": "Geoffrey", "initials": "G"}, {"family": "Bekkhus", "given": "Tove", "initials": "T"}, {"family": "Visnes", "given": "Torkild", "initials": "T"}, {"family": "Mamonov", "given": "Kirill", "initials": "K"}, {"family": "Ortis", "given": "Florian", "initials": "F"}, {"family": "Lundb\u00e4ck", "given": "Thomas", "initials": "T"}, {"family": "Volkova", "given": "Maria", "initials": "M"}, {"family": "Koolmeister", "given": "Tobias", "initials": "T"}, {"family": "Wiita", "given": "Elis\u00e9e", "initials": "E"}, {"family": "Loseva", "given": "Olga", "initials": "O"}, {"family": "Pandey", "given": "Monica", "initials": "M"}, {"family": "Homan", "given": "Evert", "initials": "E"}, {"family": "Ben\u00edtez\u2010Buelga", "given": "Carlos", "initials": "C"}, {"family": "Davies", "given": "Jonathan", "initials": "J"}, {"family": "Scobie", "given": "Martin", "initials": "M"}, {"family": "Warpman Berglund", "given": "Ulrika", "initials": "U"}, {"family": "Kalder\u00e9n", "given": "Christina", "initials": "C"}, {"family": "Stenmark", "given": "P\u00e5l", "initials": "P"}, {"family": "Helleday", "given": "Thomas", "initials": "T"}, {"family": "Michel", "given": "Maurice", "initials": "M", "orcid": "0000-0003-3261-2493", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f4696e361fe4aa3823d263674d1a498.json"}}], "type": "journal-article", "published": "2023-01-03", "journal": {"title": "ChemMedChem", "issn": "1860-7179", "volume": "18", "issue": "1", "issn-l": null}, "abstract": null, "doi": "10.1002/cmdc.202200681", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T06:31:26.534Z", "modified": "2026-08-20T06:31:26.613Z"}, {"entity": "publication", "iuid": "3f8db2bc7fb9432aac14dfab82472847", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3f8db2bc7fb9432aac14dfab82472847.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3f8db2bc7fb9432aac14dfab82472847"}}, "title": "Synthetic switches of OGG1 control initiation of base excision repair and offer new treatment strategies.", "authors": [{"family": "Benit\u00e9z-Buelga", "given": "Carlos", "initials": "C"}, {"family": "Helleday", "given": "Thomas", "initials": "T"}, {"family": "Michel", "given": "Maurice", "initials": "M", "orcid": "0000-0003-3261-2493", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f4696e361fe4aa3823d263674d1a498.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Clin Transl Med", "issn": "2001-1326", "volume": "12", "issue": "8", "pages": "e1035", "issn-l": null}, "abstract": null, "doi": "10.1002/ctm2.1035", "pmid": "36037066", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9423131"}], "notes": [], "created": "2026-08-20T06:32:08.720Z", "modified": "2026-08-20T06:32:08.793Z"}, {"entity": "publication", "iuid": "5c5bfa7eea964cf7961bdec3453b5d92", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5c5bfa7eea964cf7961bdec3453b5d92.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5c5bfa7eea964cf7961bdec3453b5d92"}}, "title": "Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.", "authors": [{"family": "Michel", "given": "Maurice", "initials": "M", "orcid": "0000-0003-3261-2493", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f4696e361fe4aa3823d263674d1a498.json"}}, {"family": "Ben\u00edtez-Buelga", "given": "Carlos", "initials": "C"}, {"family": "Calvo", "given": "Patricia A", "initials": "PA"}, {"family": "Hanna", "given": "Bishoy M F", "initials": "BMF", "orcid": "0000-0001-7027-6553", "researcher": {"href": 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"given": "Fritz", "initials": "F", "orcid": "0000-0003-0092-0627", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7f10b06057e94d03a44967cce431c1a8.json"}}, {"family": "Loseva", "given": "Olga", "initials": "O"}, {"family": "Stewart", "given": "Josephine", "initials": "J"}, {"family": "D'Arcy-Evans", "given": "Nicholas", "initials": "N"}, {"family": "Koolmeister", "given": "Tobias", "initials": "T"}, {"family": "Henriksson", "given": "Martin", "initials": "M"}, {"family": "Michel", "given": "Dana", "initials": "D"}, {"family": "de Ory", "given": "Ana", "initials": "A"}, {"family": "Acero", "given": "Lucia", "initials": "L", "orcid": "0000-0001-8101-5412", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/af80832b8d8c4019bea17c15fa7651e2.json"}}, {"family": "Calvete", "given": "Oriol", "initials": "O", "orcid": "0000-0002-2623-2876", "researcher": {"href": 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"Ana", "initials": "A", "orcid": "0000-0001-8124-3984", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ecd4cc9c17d43009703efb95d979e09.json"}}, {"family": "Perona", "given": "Rosario", "initials": "R", "orcid": "0000-0002-2973-5153", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b116837f5c346d49e70ad5eb28d7afb.json"}}, {"family": "Stolz", "given": "Alexandra", "initials": "A", "orcid": "0000-0002-3340-439X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4bde36f21953479a8762c1c858b4c451.json"}}, {"family": "Stenmark", "given": "P\u00e5l", "initials": "P", "orcid": "0000-0003-4777-3417", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9791bc0d7463417899d6953b5ca1bac3.json"}}, {"family": "Berglund", "given": "Ulrika Warpman", "initials": "UW", "orcid": "0000-0002-6372-1396", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b6cab92fb2c4597a0c04777095f80db.json"}}, {"family": "de Vega", "given": "Miguel", "initials": "M", "orcid": "0000-0003-1285-7549", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6196fa790b4645c3acef45a87cdac3d0.json"}}, {"family": "Helleday", "given": "Thomas", "initials": "T", "orcid": "0000-0002-7384-092X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/385586c159494955a9a72c3381e3ad47.json"}}], "type": "journal article", "published": "2022-06-24", "journal": {"title": "Science (New York, N.Y.)", "issn": "1095-9203", "volume": "376", "issue": "6600", "pages": "1471-1476", "issn-l": "0036-8075"}, "abstract": "Oxidative DNA damage is recognized by 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), which excises 8-oxoG, leaving a substrate for apurinic endonuclease 1 (APE1) and initiating repair. Here, we describe a small molecule (TH10785) that interacts with the phenylalanine-319 and glycine-42 amino acids of OGG1, increases the enzyme activity 10-fold, and generates a previously undescribed \u03b2,\u03b4-lyase enzymatic function. TH10785 controls the catalytic activity mediated by a nitrogen base within its molecular structure. In cells, TH10785 increases OGG1 recruitment to and repair of oxidative DNA damage. This alters the repair process, which no longer requires APE1 but instead is dependent on polynucleotide kinase phosphatase (PNKP1) activity. The increased repair of oxidative DNA lesions with a small molecule may have therapeutic applications in various diseases and aging.", "doi": "10.1126/science.abf8980", "pmid": "35737787", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T11:59:29.051Z", "modified": "2026-08-20T11:59:30.134Z"}, {"entity": "publication", "iuid": "d100d0e2fd664a2a8ec1ede877d471b4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d100d0e2fd664a2a8ec1ede877d471b4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d100d0e2fd664a2a8ec1ede877d471b4"}}, "title": "NUDT18 catalyzes the hydrolysis of active metabolites of the antivirals Remdesivir, Ribavirin and Molnupiravir", "authors": [{"family": "Jemth", "given": "Ann Sofie", "initials": "AS"}, {"family": "Scaletti", "given": "Emma Rose", "initials": "ER"}, {"family": "Homan", "given": "Evert", "initials": "E"}, {"family": "Stenmark", "given": "P\u00e5l", "initials": "P"}, {"family": "Helleday", "given": "Thomas", "initials": "T"}, {"family": "Michel", "given": "Maurice", "initials": "M", "orcid": "0000-0003-3261-2493", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f4696e361fe4aa3823d263674d1a498.json"}}], "type": "posted-content", "published": "2021-11-17", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.11.16.468802", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:07:37.380Z", "modified": "2026-08-20T10:07:37.432Z"}, {"entity": "publication", "iuid": "772c66fd0f16493a84a86f88ac367a62", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/772c66fd0f16493a84a86f88ac367a62.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/772c66fd0f16493a84a86f88ac367a62"}}, "title": "NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487.", "authors": [{"family": "Hanna", "given": "Bishoy M F", "initials": "BMF", "orcid": "0000-0001-7027-6553", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/61301102836e44d189f5628bb33c1335.json"}}, {"family": "Michel", "given": "Maurice", "initials": "M", "orcid": "0000-0003-3261-2493", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f4696e361fe4aa3823d263674d1a498.json"}}, {"family": "Helleday", "given": "Thomas", "initials": "T"}, {"family": "Mortusewicz", "given": "Oliver", "initials": "O", "orcid": "0000-0002-4290-4994", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f546fe8f2c54824b942f7f88976e3bd.json"}}], "type": "journal article", "published": "2021-04-27", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "22", "issue": "9", "issn-l": null}, "abstract": "DNA damage caused by reactive oxygen species may result in genetic mutations or cell death. Base excision repair (BER) is the major pathway that repairs DNA oxidative damage in order to maintain genomic integrity. In mammals, eleven DNA glycosylases have been reported to initiate BER, where each recognizes a few related DNA substrate lesions with some degree of overlapping specificity. 7,8-dihydro-8-oxoguanine (8-oxoG), one of the most abundant DNA oxidative lesions, is recognized and excised mainly by 8-oxoguanine DNA glycosylase 1 (OGG1). Further oxidation of 8-oxoG generates hydantoin lesions, which are recognized by NEIL glycosylases. Here, we demonstrate that NEIL1, and to a lesser extent NEIL2, can potentially function as backup BER enzymes for OGG1 upon pharmacological inhibition or depletion of OGG1. NEIL1 recruitment kinetics and chromatin binding after DNA damage induction increase in cells treated with OGG1 inhibitor TH5487 in a dose-dependent manner, whereas NEIL2 accumulation at DNA damage sites is prolonged following OGG1 inhibition. Furthermore, depletion of OGG1 results in increased retention of NEIL1 and NEIL2 at damaged chromatin. Importantly, oxidatively stressed NEIL1- or NEIL2-depleted cells show excessive genomic 8-oxoG lesions accumulation upon OGG1 inhibition, suggesting a prospective compensatory role for NEIL1 and NEIL2. Our study thus exemplifies possible backup mechanisms within the base excision repair pathway.", "doi": "10.3390/ijms22094542", "pmid": "33925271", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8123590"}, {"db": "pii", "key": "ijms22094542"}], "notes": [], "created": "2026-08-20T13:41:20.078Z", "modified": "2026-08-20T13:41:20.130Z"}, {"entity": "publication", "iuid": "fe8c1f571b384e308c0d9fcebca2f74c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/fe8c1f571b384e308c0d9fcebca2f74c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/fe8c1f571b384e308c0d9fcebca2f74c"}}, "title": "In Silico Druggability Assessment of the NUDIX Hydrolase Protein Family as a Workflow for Target Prioritization", "authors": [{"family": "Michel", "given": "Maurice", "initials": "M", "orcid": "0000-0003-3261-2493", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f4696e361fe4aa3823d263674d1a498.json"}}, {"family": "Homan", "given": "Evert J", "initials": "EJ"}, {"family": "Wiita", "given": "Elisee", "initials": "E"}, {"family": "Pedersen", "given": "Kia", "initials": "K"}, {"family": "Almlo\u0308f", "given": "Ingrid", "initials": "I"}, {"family": "Gustavsson", "given": "Anna Lena", "initials": "AL"}, {"family": "Lundb\u00e4ck", "given": "Thomas", "initials": "T"}, {"family": "Helleday", "given": "Thomas", "initials": "T"}, {"family": "Berglund", "given": "Ulrika Warpman", "initials": "UW"}], "type": "posted-content", "published": "2019-10-25", "journal": {"issn-l": null}, "abstract": null, "doi": "10.26434/chemrxiv.10026929.v1", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:03:10.727Z", "modified": "2026-08-20T13:03:12.498Z"}]}