{"entity": "publication", "iuid": "502327f3318743059356bc1f313337e3", "timestamp": "2026-05-09T16:29:25.097Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/502327f3318743059356bc1f313337e3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/502327f3318743059356bc1f313337e3"}}, "title": "From transcriptional complexity to cellular phenotypes: Lessons from yeast.", "authors": [{"family": "Pelechano", "given": "Vicent", "initials": "V", "orcid": "0000-0002-9415-788X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e893b93b7654d10b4072e1b5de0bd71.json"}}], "type": "journal article", "published": "2017-12-00", "journal": {"title": "Yeast", "issn": "1097-0061", "issn-l": "0749-503X", "volume": "34", "issue": "12", "pages": "475-482"}, "abstract": "Pervasive transcription has been reported in many eukaryotic organisms, revealing a highly interleaved transcriptome organization that involves thousands of coding and non-coding RNAs. However, to date, the biological impact of transcriptome complexity is still poorly understood. Here I will review how subtle variations of the transcriptome can lead to divergent cellular phenotypes by fine-tuning both its coding potential and regulation. I will discuss strategies that can be used to link molecular variations with divergent biological outcomes. Finally, I will explore the implication of transcriptional complexity for our understanding of gene expression in the context of cell-to-cell phenotypic variability. Copyright \u00a9 2017 John Wiley & Sons, Ltd.", "doi": "10.1002/yea.3277", "pmid": "28866863", "labels": {"Affiliated researcher": null, "Vicent Pelechano": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2018-12-03T14:42:14.858Z", "modified": "2022-11-04T11:32:18.302Z"}