von Heijne G

Family name	von Heijne
Given name	Gunnar
Initials	G
ORCID	ORCID 0000-0002-4490-8569
Affiliations	Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden. Science for Life Laboratory, Stockholm University, Solna, Sweden.

42 publications

PubMed DOI Crossref

Cotranslational folding and maturation of HIV-1 protease.

Westerfield J, Nicolaus F, Swanstrom R, von Heijne G

bioRxiv - (-) - [2025-08-27; online 2025-08-27]

PubMed DOI Crossref

Cotranslational membrane insertion of the voltage-sensitive K+ channel KvAP.

Westerfield JM, Kozojedová P, Juli C, Metola A, von Heijne G

Proc. Natl. Acad. Sci. U.S.A. 122 (14) e2412492122 [2025-04-08; online 2025-03-31]

PubMed DOI Crossref

Sequence-dependent scale for translocon-mediated insertion of interfacial helices in membranes.

Grau B, Kormos R, Bañó-Polo M, ..., DeGrado WF, Mingarro I

Sci Adv 11 (8) eads6804 [2025-02-21; online 2025-02-19]

PubMed DOI Crossref

Spc2 modulates substrate- and cleavage site-selection in the yeast signal peptidase complex.

Chung Y, Yim C, Pereira GP, ..., Souza PCT, Kim H

J. Cell Biol. 223 (12) - [2024-12-02; online 2024-11-20]

DOI Crossref

Sequence-dependent scale for translocon-mediated insertion of interfacial helices in membranes

Grau B, Kormos R, Bañó-Polo M, ..., DeGrado WF, Mingarro I

- - (-) - [2024-10-25; online 2024-10-25]

PubMed DOI Crossref

Single-residue effects on the behavior of a nascent polypeptide chain inside the ribosome exit tunnel.

Pardo-Avila F, Kudva R, Levitt M, von Heijne G

bioRxiv - (-) - [2024-08-20; online 2024-08-20]

DOI Crossref

Cotranslational membrane insertion of the voltage-sensitive K + channel KvAP

Westerfield JM, Kozojedová P, Juli C, Metola A, von Heijne G

- - (-) - [2024-05-29; online 2024-05-29]

PubMed DOI Crossref

Cotranslational folding of human growth hormone in vitro and in Escherichia coli.

Mermans D, Nicolaus F, Baygin A, von Heijne G

FEBS Lett. 597 (10) 1355-1362 [2023-05-00; online 2022-12-22]

PubMed DOI Crossref

Cotranslational folding and assembly of the dimeric Escherichia coli inner membrane protein EmrE.

Mermans D, Nicolaus F, Fleisch K, von Heijne G

Proc. Natl. Acad. Sci. U.S.A. 119 (35) e2205810119 [2022-08-30; online 2022-08-22]

DOI Crossref

Cotranslational folding of human growth hormone in vitro and in Escherichia coli

Mermans D, Nicolaus F, Baygin A, von Heijne G

- - (-) - [2022-08-08; online 2022-08-08]

DOI Crossref

Cotranslational folding and assembly of the dimeric E. coli inner membrane protein EmrE

Mermans D, Nicolaus F, Fleisch K, von Heijne G

- - (-) - [2022-04-02; online 2022-04-02]

PubMed DOI Crossref

Upstream charged and hydrophobic residues impact the timing of membrane insertion of transmembrane helices.

Nicolaus F, Ibrahimi F, den Besten A, von Heijne G

FEBS Lett. 596 (8) 1004-1012 [2022-04-00; online 2022-01-31]

DOI Crossref

Upstream charged and hydrophobic residues impact the timing of membrane insertion of transmembrane helices

Nicolaus F, Ibrahimi F, den Besten A, von Heijne G

- - (-) - [2021-12-24; online 2021-12-24]

DOI Crossref

SignalP 6.0 achieves signal peptide prediction across all types using protein language models

Teufel F, Armenteros JJA, Johansen AR, ..., von Heijne G, Nielsen H

- - (-) - [2021-06-10; online 2021-06-10]

PubMed DOI Crossref

Residue-by-residue analysis of cotranslational membrane protein integration in vivo.

Nicolaus F, Metola A, Mermans D, ..., Miller Iii TF, von Heijne G

Elife 10 (-) - [2021-02-08; online 2021-02-08]

DOI Crossref

Cotranslational folding of a periplasmic protein domain in Escherichia coli

Sandhu H, Hedman R, Cymer F, ..., Ismail N, von Heijne G

- - (-) - [2021-02-06; online 2021-02-06]

DOI Crossref

Author response: Residue-by-residue analysis of cotranslational membrane protein integration in vivo

Nicolaus F, Metola A, Mermans D, ..., Miller III TF, von Heijne G

- - (-) - [2021-02-01; online 2021-02-01]

PubMed DOI Crossref

Cotranslational folding of alkaline phosphatase in the periplasm of Escherichia coli.

Elfageih R, Karyolaimos A, Kemp G, ..., von Heijne G, Kudva R

Protein Sci. 29 (10) 2028-2037 [2020-10-00; online 2020-08-24]

DOI Crossref

Residue-by-residue analysis of cotranslational membrane protein integration in vivo

Nicolaus F, Metola A, Mermans D, ..., Miller TF, von Heijne G

- - (-) - [2020-09-28; online 2020-09-28]

DOI Crossref

Cotranslational folding of alkaline phosphatase in the periplasm of Escherichia coli

Elfageih R, Karyolaimos A, Kemp G, ..., von Heijne G, Kudva R

- - (-) - [2020-07-06; online 2020-07-06]

DOI Crossref

The ribosome modulates folding inside the ribosomal exit tunnel

Wruck F, Tian P, Kudva R, ..., Tans SJ, Katranidis A

- - (-) - [2020-07-01; online 2020-07-01]

PubMed DOI Crossref

Cotranslational folding cooperativity of contiguous domains of α-spectrin.

Kemp G, Nilsson OB, Tian P, Best RB, von Heijne G

Proc. Natl. Acad. Sci. U.S.A. 117 (25) 14119-14126 [2020-06-23; online 2020-06-08]

PubMed DOI Crossref

Detecting sequence signals in targeting peptides using deep learning.

Almagro Armenteros JJ, Salvatore M, Emanuelsson O, ..., Elofsson A, Nielsen H

Life Sci. Alliance 2 (5) - [2019-10-00; online 2019-09-30]

PubMed DOI Crossref

Dynamic membrane topology in an unassembled membrane protein.

Seurig M, Ek M, von Heijne G, Fluman N

Nat. Chem. Biol. 15 (10) 945-948 [2019-10-00; online 2019-09-09]

PubMed DOI Crossref

Structural and mutational analysis of the ribosome-arresting human XBP1u.

Shanmuganathan V, Schiller N, Magoulopoulou A, ..., von Heijne G, Beckmann R

Elife 8 (-) - [2019-06-27; online 2019-06-27]

DOI Crossref

Author response: Structural and mutational analysis of the ribosome-arresting human XBP1u

Shanmuganathan V, Schiller N, Magoulopoulou A, ..., von Heijne G, Beckmann R

- - (-) - [2019-06-19; online 2019-06-19]

DOI Crossref

Membrane integration and topology of RIFIN and STEVOR proteins of the Plasmodium falciparum parasite

Andersson A, Kudva R, Magoulopoulou A, ..., Nilsson I, Tellgren-Roth Å

- - (-) - [2019-05-29; online 2019-05-29]

DOI Crossref

Cotranslational folding cooperativity of contiguous domains of α-spectrin

Kemp G, Nilsson OB, Tian P, Best RB, von Heijne G

- - (-) - [2019-05-29; online 2019-05-29]

DOI Crossref

Detecting Novel Sequence Signals in Targeting Peptides Using Deep Learning

Almagro Armenteros JJ, Salvatore M, Emanuelsson O, ..., Elofsson A, Nielsen H

- - (-) - [2019-05-17; online 2019-05-17]

DOI Crossref

Dynamic membrane topology in an unassembled membrane protein

Seurig M, Ek M, von Heijne G, Fluman N

- - (-) - [2019-02-13; online 2019-02-13]

PubMed DOI Crossref

The shape of the bacterial ribosome exit tunnel affects cotranslational protein folding.

Kudva R, Tian P, Pardo-Avila F, ..., Bernstein HD, von Heijne G

Elife 7 (-) - [2018-11-26; online 2018-11-26]

DOI Crossref

Force-profile analysis of the cotranslational folding of HemK and filamin domains: Comparison of biochemical and biophysical folding assays

Kemp G, Kudva R, Rosa Adl, Heijne Gv

- - (-) - [2018-11-15; online 2018-11-15]

PubMed DOI Crossref

Effects of protein size, thermodynamic stability, and net charge on cotranslational folding on the ribosome.

Farías-Rico JA, Ruud Selin F, Myronidi I, Frühauf M, von Heijne G

Proc. Natl. Acad. Sci. U.S.A. 115 (40) E9280-E9287 [2018-10-02; online 2018-09-17]

DOI Crossref

Author response: The shape of the bacterial ribosome exit tunnel affects cotranslational protein folding

Kudva R, Tian P, Pardo-Avila F, ..., Bernstein HD, von Heijne G

- - (-) - [2018-06-13; online 2018-06-13]

DOI Crossref

Effects of protein size, thermodynamic stability, and net charge on cotranslational folding on the ribosome

Farías-Rico JA, Selin FR, Myronidi I, Frühauf M, Heijne Gv

- - (-) - [2018-04-18; online 2018-04-18]

DOI Crossref

Cotranslational folding of a pentarepeat β-helix protein

Notari L, Martínez-Carranza M, Farias-Rico JA, Stenmark P, von Heijne G

- - (-) - [2018-01-29; online 2018-01-29]

DOI Crossref

Mutational analysis of the human Xbp1 translational arrest peptide and construction of arrest-enhanced variants

Schiller N, Magoulopoulou A, Cymer F, Von Heijne G

- - (-) - [2017-10-11; online 2017-10-11]

PubMed DOI Crossref

Structure and topology around the cleavage site regulate post-translational cleavage of the HIV-1 gp160 signal peptide.

Snapp EL, McCaul N, Quandte M, ..., Sanders RW, Braakman I

Elife 6 (-) - [2017-07-28; online 2017-07-28]

Affiliated researcher

DOI Crossref

Author response: Structure and topology around the cleavage site regulate post-translational cleavage of the HIV-1 gp160 signal peptide

Snapp EL, McCaul N, Quandte M, ..., Sanders RW, Braakman I

- - (-) - [2017-07-21; online 2017-07-21]

PubMed DOI Crossref

The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling.

Su T, Cheng J, Sohmen D, ..., Wilson DN, Beckmann R

Elife 6 (-) - [2017-05-30; online 2017-05-30]

Affiliated researcher

DOI Crossref

Author response: The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling

Su T, Cheng J, Sohmen D, ..., Wilson DN, Beckmann R

- - (-) - [2017-05-17; online 2017-05-17]

DOI Crossref

Stable membrane topologies of small dual-topology membrane proteins

Fluman N, Tobiasson V, von Heijne G

- - (-) - [2017-05-02; online 2017-05-02]