Pfenning AR

Leveraging base-pair mammalian constraint to understand genetic variation and human disease.

Sullivan PF, Meadows JRS, Gazal S, ..., Karlsson EK, Lindblad-Toh K

Science (New York, N.Y.) 380 (6643) eabn2937 [2023-04-28; online 2023-04-28]

Relating enhancer genetic variation across mammals to complex phenotypes using machine learning.

Kaplow IM, Lawler AJ, Schäffer DE, ..., Meyer WK, Pfenning AR

Science (New York, N.Y.) 380 (6643) eabm7993 [2023-04-28; online 2023-04-28]

Evolutionary constraint and innovation across hundreds of placental mammals.

Christmas MJ, Kaplow IM, Genereux DP, ..., Lindblad-Toh K, Karlsson EK

Science (New York, N.Y.) 380 (6643) eabn3943 [2023-04-28; online 2023-04-28]

Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates.

Damas J, Hughes GM, Keough KC, ..., Karlsson EK, Lewin HA

Proc. Natl. Acad. Sci. U.S.A. 117 (36) 22311-22322 [2020-09-08; online 2020-08-21]