{"entity": "publication", "iuid": "5cf04d9b5c12461d9d229abd043fca24", "timestamp": "2026-05-09T17:18:35.756Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5cf04d9b5c12461d9d229abd043fca24.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5cf04d9b5c12461d9d229abd043fca24"}}, "title": "Tetrahydrobenzothiophene carboxamides: Beyond the kinase domain and into the fatty acid realm.", "authors": [{"family": "Llona-Minguez", "given": "Sabin", "initials": "S"}, {"family": "Fayezi", "given": "Shabnam", "initials": "S"}, {"family": "Alihemmati", "given": "Alireza", "initials": "A"}, {"family": "Ju\u00e1rez-Jim\u00e9nez", "given": "Jordi", "initials": "J"}, {"family": "Piedrafita", "given": "F Javier", "initials": "FJ"}, {"family": "Helleday", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2017-09-15", "journal": {"title": "Bioorg. Med. Chem. Lett.", "issn": "1464-3405", "volume": "27", "issue": "18", "pages": "4462-4466", "issn-l": "0960-894X"}, "abstract": "A series of tetrahydrobenzothiophene carboxamides, inspired by structural features present in kinase and SCD1 inhibitors, are presented here. Prototype compound 8 (MMDD13) modulates fatty acid elongase and desaturase indexes, lipid accumulation, while preserving kinase inhibitory activity. This chemotype represents a stepping stone towards chemical probes to study the consequences of lipid metabolism modulation through non-redundant pathways.", "doi": "10.1016/j.bmcl.2017.08.006", "pmid": "28807439", "labels": {"Affiliated researcher": null}, "xrefs": [{"db": "pii", "key": "S0960-894X(17)30795-3"}], "notes": [], "created": "2018-12-05T12:55:52.328Z", "modified": "2018-12-05T12:55:52.349Z"}