Löfblom J

Targeting Tumor Cells Overexpressing the Human Epidermal Growth Factor Receptor 3 with Potent Drug Conjugates Based on Affibody Molecules.

Rinne SS, Yin W, Borras AM, ..., Orlova A, Gräslund T

Biomedicines 10 (6) - [2022-05-31; online 2022-05-31]

HER3 PET Imaging: 68Ga-Labeled Affibody Molecules Provide Superior HER3 Contrast to 89Zr-Labeled Antibody and Antibody-Fragment-Based Tracers.

Rinne SS, Leitao CD, Abouzayed A, ..., Löfblom J, Orlova A

Cancers (Basel) 13 (19) - [2021-09-24; online 2021-09-24]

Evaluating the Therapeutic Efficacy of Mono- and Bivalent Affibody-Based Fusion Proteins Targeting HER3 in a Pancreatic Cancer Xenograft Model.

Leitao CD, Rinne SS, Altai M, ..., Ståhl S, Orlova A

Pharmaceutics 12 (6) - [2020-06-13; online 2020-06-13]

Benefit of Later-Time-Point PET Imaging of HER3 Expression Using Optimized Radiocobalt-Labeled Affibody Molecules.

Rinne SS, Dahlsson Leitao C, Saleh-Nihad Z, ..., Löfblom J, Orlova A

Int J Mol Sci 21 (6) - [2020-03-13; online 2020-03-13]

Influence of Residualizing Properties of the Radiolabel on Radionuclide Molecular Imaging of HER3 Using Affibody Molecules.

Rinne SS, Xu T, Dahlsson Leitao C, ..., Tolmachev V, Vorobyeva A

Int J Mol Sci 21 (4) - [2020-02-15; online 2020-02-15]

Increase in negative charge of 68Ga/chelator complex reduces unspecific hepatic uptake but does not improve imaging properties of HER3-targeting affibody molecules.

Rinne SS, Dahlsson Leitao C, Gentry J, ..., Löfblom J, Orlova A

Sci Rep 9 (1) 17710 [2019-11-27; online 2019-11-27]

Optimal composition and position of histidine-containing tags improves biodistribution of 99mTc-labeled DARPin G3.

Vorobyeva A, Schulga A, Konovalova E, ..., Tolmachev V, Deyev SM

Sci Rep 9 (1) 9405 [2019-06-28; online 2019-06-28]

Improved contrast of affibody-mediated imaging of HER3 expression in mouse xenograft model through co-injection of a trivalent affibody for in vivo blocking of hepatic uptake.

Rosestedt M, Andersson KG, Rinne SS, ..., Tolmachev V, Orlova A

Sci Rep 9 (1) 6779 [2019-05-01; online 2019-05-01]

Molecular Design of HER3-Targeting Affibody Molecules: Influence of Chelator and Presence of HEHEHE-Tag on Biodistribution of 68Ga-Labeled Tracers.

Dahlsson Leitao C, Rinne SS, Mitran B, ..., Löfblom J, Orlova A

Int J Mol Sci 20 (5) - [2019-03-02; online 2019-03-02]

Optimization of HER3 expression imaging using affibody molecules: Influence of chelator for labeling with indium-111.

Rinne SS, Leitao CD, Mitran B, ..., Löfblom J, Orlova A

Sci Rep 9 (1) 655 [2019-01-24; online 2019-01-24]

Influence of Molecular Design on the Targeting Properties of ABD-Fused Mono- and Bi-Valent Anti-HER3 Affibody Therapeutic Constructs.

Altai M, Leitao CD, Rinne SS, ..., Löfblom J, Orlova A

Cells 7 (10) - [2018-10-11; online 2018-10-11]