The power of two: Combining imaging and sequencing as readouts for in vivo pooled genetic screens.

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Jiménez C, Crosetto N, Bienko M

Mol. Cell 85 (16) 3006-3008 [2025-08-21; online 2025-08-23]

In a recent publication in Cell, Saunders et al.1 describe an important step forward for in vivo genetic screens, by enabling parallel tissue imaging and sequencing, boosting the discovery of gene-phenotype links that had previously gone unnoticed.

PubMed 40845801

DOI 10.1016/j.molcel.2025.07.020

Crossref 10.1016/j.molcel.2025.07.020

pii: S1097-2765(25)00621-5