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Yakneen S, Waszak SM, PCAWG Technical Working Group , Gertz M, Korbel JO, PCAWG Consortium
Nat. Biotechnol. 38 (3) 288-292 [2020-03-00; online 2020-02-05]
We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.
PubMed 32024987
DOI 10.1038/s41587-019-0360-3
Crossref 10.1038/s41587-019-0360-3
pmc: PMC7062635
pii: 10.1038/s41587-019-0360-3