{"entity": "publication", "iuid": "14ef67e20d2a4fedaed46deeb57deab3", "timestamp": "2026-09-23T15:59:30.056Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/14ef67e20d2a4fedaed46deeb57deab3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/14ef67e20d2a4fedaed46deeb57deab3"}}, "title": "Butler enables rapid cloud-based analysis of thousands of human genomes.", "authors": [{"family": "Yakneen", "given": "Sergei", "initials": "S", "orcid": "0000-0001-7827-9839", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f51821a096734d94ad0bc351125226b9.json"}}, {"family": "Waszak", "given": "Sebastian M", "initials": "SM"}, {"family": "PCAWG Technical Working Group", "given": "", "initials": ""}, {"family": "Gertz", "given": "Michael", "initials": "M"}, {"family": "Korbel", "given": "Jan O", "initials": "JO", "orcid": "0000-0002-2798-3794", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e435cc008754cc0b15994e18bf19a44.json"}}, {"family": "PCAWG Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2020-03-00", "journal": {"title": "Nat. Biotechnol.", "issn": "1546-1696", "volume": "38", "issue": "3", "pages": "288-292", "issn-l": "1087-0156"}, "abstract": "We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.", "doi": "10.1038/s41587-019-0360-3", "pmid": "32024987", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7062635"}, {"db": "pii", "key": "10.1038/s41587-019-0360-3"}], "notes": [], "created": "2026-09-23T12:42:58.792Z", "modified": "2026-09-23T12:42:58.914Z"}