Larhed M

Family name	Larhed
Given name	Mats
Initials	M
ORCID	ORCID 0000-0001-6258-0635
Affiliations	Department of Medicinal Chemistry, Science for Life Laboratory, BMC, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden.

18 publications

PubMed DOI Crossref

Novel macrocyclic peptidomimetics targeting the insulin-regulated aminopeptidase (IRAP): design, synthesis and evaluation.

Olaniran Håkansson E, Balestri LJI, Puthiyaparambath S, ..., Skillinghaug B, Odell LR

RSC Med Chem 16 (10) 5059-5069 [2025-10-15; online 2025-08-06]

DOI Crossref

Benzylhydroxamic Acids as IRAP Inhibitors: Sulfonamide Variations

Larhed M, Gising J, Beveridge J, ..., Odell LR, Hallberg M

Synlett 36 (16) 2666-2670 [2025-10-00; online 2025-04-15]

DOI Crossref

A Diastereoselective Mizoroki–Heck Reaction for Synthesis of Spirooxindole-Based Nonnatural Amino Acids Using a Boc-Protected Amine Chiral Auxiliary

Larhed M, Lindman J, Puthiyaparambath S, Gising J, Odell LR

Synlett 36 (14) 2009-2013 [2025-09-00; online 2025-04-29]

PubMed DOI Crossref

Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells.

Stam F, Bjurling S, Nylander E, ..., Grönbladh A, Hallberg M

Int J Mol Sci 25 (22) - [2024-11-08; online 2024-11-08]

DOI Crossref

Inhibition of IRAP Enhance the Expression of Pro-cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells

Stam F, Bjurling S, Nylander E, ..., Grönbladh A, Hallberg M

- - (-) - [2024-07-31; online 2024-07-31]

PubMed DOI Crossref

The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds.

Gising J, Honarnejad S, Bras M, ..., Hallberg M, Larhed M

Int J Mol Sci 25 (7) - [2024-04-06; online 2024-04-06]

PubMed DOI Crossref

Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures.

Stam F, Florén Lind S, Schroff A, ..., Larhed M, Hallberg M

Curr Issues Mol Biol 44 (10) 5000-5012 [2022-10-18; online 2022-10-18]

PubMed DOI Crossref

Synthesis and In Vitro Biological Evaluation of Quinolinyl Pyrimidines Targeting Type II NADH-Dehydrogenase (NDH-2).

Lu L, Åkerbladh L, Ahmad S, ..., Karlén A, Mowbray SL

ACS Infect Dis 8 (3) 482-498 [2022-03-11; online 2022-02-21]

PubMed DOI Crossref

Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model.

Lundmark F, Abouzayed A, Mitran B, ..., Rosenström U, Orlova A

Pharmaceutics 12 (7) - [2020-07-01; online 2020-07-01]

PubMed DOI Crossref

Regio- and Stereoselective Synthesis of Allylic Spiroethers (Spirobenzofuranes) via an Intramolecular Mizoroki-Heck Reaction.

Adeyemi A, Odell LR, Larhed M

J. Org. Chem. 85 (12) 7648-7657 [2020-06-19; online 2020-06-01]

PubMed DOI Crossref

Macrocyclic peptidomimetics as inhibitors of insulin-regulated aminopeptidase (IRAP).

Barlow N, Vanga SR, Sävmarker J, ..., Chai SY, Thompson PE

RSC Med Chem 11 (2) 234-244 [2020-02-01; online 2020-01-08]

PubMed DOI Crossref

Bispecific GRPR-Antagonistic Anti-PSMA/GRPR Heterodimer for PET and SPECT Diagnostic Imaging of Prostate Cancer.

Mitran B, Varasteh Z, Abouzayed A, ..., Orlova A, Rosenström U

Cancers (Basel) 11 (9) - [2019-09-14; online 2019-09-14]

PubMed DOI Crossref

Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer.

Abouzayed A, Yim CB, Mitran B, ..., Rosenström U, Orlova A

Pharmaceutics 11 (7) - [2019-07-23; online 2019-07-23]

DOI Crossref

Regio- and Stereoselective Synthesis of Spirooxindoles via Mizoroki–Heck Coupling of Aryl Iodides

Larhed M, Adeyemi A, Wetzel A, Bergman J, Brånalt J

Synlett 30 (01) 82-88 [2019-01-00; online 2018-12-04]

PubMed DOI Crossref

Route to 3-Amidino Indoles via Pd(II)-Catalyzed C-H Bond Activation.

Rydfjord J, Skillinghaug B, Brandt P, Odell LR, Larhed M

Org. Lett. 19 (15) 4066-4069 [2017-08-04; online 2017-07-25]

DOI Crossref

Continuous Flow Synthesis under High-Temperature/High-Pressure Conditions Using a Resistively Heated Flow Reactor

Adeyemi A, Bergman J, Brånalt J, Sävmarker J, Larhed M

Org. Process Res. Dev. 21 (7) 947-955 [2017-07-21; online 2017-06-29]

PubMed DOI Crossref

Selective Synthesis of Spirooxindoles by an Intramolecular Heck-Mizoroki Reaction.

Roy T, Brandt P, Wetzel A, ..., Sävmarker J, Larhed M

Org. Lett. 19 (10) 2738-2741 [2017-05-19; online 2017-05-04]

PubMed DOI Crossref

Regio- and Stereoselective Synthesis of Functionalized Cyclopentene Derivatives via Mizoroki-Heck Reactions.

Wetzel A, Bergman J, Brandt P, Larhed M, Brånalt J

Org. Lett. 19 (7) 1602-1605 [2017-04-07; online 2017-03-14]