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Rendo V, Stoimenov I, Sjöblom T
Mol Cell Oncol 7 (4) 1759390 [2020-05-13; online 2020-05-13]
We show that N-acetyltransferase 2 (NAT2) loss of heterozygosity can be targeted in >4% of colorectal cancers with the use of a small molecule. We identify and describe the effect of a compound that impairs the growth of colorectal tumors with slow NAT2 activity by half when compared to wild-type.
PubMed 32944621
DOI 10.1080/23723556.2020.1759390
Crossref 10.1080/23723556.2020.1759390
pmc: PMC7469497
pii: 1759390