{"entity": "publication", "iuid": "eaeb311846cd44cb87eac4d2b38a84c0", "timestamp": "2026-08-20T20:57:15.724Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/eaeb311846cd44cb87eac4d2b38a84c0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/eaeb311846cd44cb87eac4d2b38a84c0"}}, "title": "Targeting tumor vulnerabilities associated with loss of heterozygosity.", "authors": [{"family": "Rendo", "given": "Veronica", "initials": "V", "orcid": "0000-0002-2983-4020", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c4c9ca49eb64227be6574a4384ffb46.json"}}, {"family": "Stoimenov", "given": "Ivaylo", "initials": "I", "orcid": "0000-0002-2133-7396", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/10ad1a77c6f241418187734e9a47c16c.json"}}, {"family": "Sj\u00f6blom", "given": "Tobias", "initials": "T"}], "type": "journal article", "published": "2020-05-13", "journal": {"title": "Mol Cell Oncol", "issn": "2372-3556", "volume": "7", "issue": "4", "pages": "1759390", "issn-l": null}, "abstract": "We show that N-acetyltransferase 2 (NAT2) loss of heterozygosity can be targeted in >4% of colorectal cancers with the use of a small molecule. We identify and describe the effect of a compound that impairs the growth of colorectal tumors with slow NAT2 activity by half when compared to wild-type.", "doi": "10.1080/23723556.2020.1759390", "pmid": "32944621", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7469497"}, {"db": "pii", "key": "1759390"}], "notes": [], "created": "2026-08-20T09:37:51.051Z", "modified": "2026-08-20T09:37:51.114Z"}