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Shahbazy M, Leo IR, Faridi P, Caron E
Trends Immunol. 46 (6) 435-437 [2025-06-00; online 2025-05-13]
Recently, Kondo et al. engineered the coexpression of a T cell receptor (TCR) and a chimeric antigen receptor (CAR) and developed an antagonism-enforced braking system where TCR signals both enhance and inhibit CAR activation. This work may enable rational design of CAR-T agents that limit toxicity to healthy tissue.
PubMed 40368698
DOI 10.1016/j.it.2025.04.007
Crossref 10.1016/j.it.2025.04.007
pii: S1471-4906(25)00120-6