{"entity": "publication", "iuid": "ded6c31990664f4789a952011427c17a", "timestamp": "2026-08-29T04:16:51.012Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ded6c31990664f4789a952011427c17a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ded6c31990664f4789a952011427c17a"}}, "title": "Using TCR-CAR dual signaling for precise cancer targeting.", "authors": [{"family": "Shahbazy", "given": "Mohammad", "initials": "M"}, {"family": "Leo", "given": "Isabelle Rose", "initials": "IR"}, {"family": "Faridi", "given": "Pouya", "initials": "P"}, {"family": "Caron", "given": "Etienne", "initials": "E"}], "type": "journal article", "published": "2025-06-00", "journal": {"title": "Trends Immunol.", "issn": "1471-4981", "volume": "46", "issue": "6", "pages": "435-437", "issn-l": "1471-4906"}, "abstract": "Recently, Kondo et al. engineered the coexpression of a T cell receptor (TCR) and a chimeric antigen receptor (CAR) and developed an antagonism-enforced braking system where TCR signals both enhance and inhibit CAR activation. This work may enable rational design of CAR-T agents that limit toxicity to healthy tissue.", "doi": "10.1016/j.it.2025.04.007", "pmid": "40368698", "labels": [], "xrefs": [{"db": "pii", "key": "S1471-4906(25)00120-6"}], "notes": [], "created": "2026-08-21T11:21:26.696Z", "modified": "2026-08-21T11:21:26.735Z"}