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Kaminskiy Y, Kuznetsova V, Kudriaeva A, Zmievskaya E, Bulatov E
Front Immunol 13 (-) 971045 [2022-10-04; online 2022-10-04]
FOXP1 is ubiquitously expressed in the human body and is implicated in both physiological and pathological processes including cancer. However, despite its importance the role of FOXP1 in T-cells has not been extensively studied. Although relatively few phenotypic and mechanistic details are available, FOXP1 role in T-cell quiescence and differentiation of CD4+ subsets has recently been established. FOXP1 prevents spontaneous T-cell activation, preserves memory potential, and regulates the development of follicular helper and regulatory T-cells. Moreover, there is growing evidence that FOXP1 also regulates T-cell exhaustion. Altogether this makes FOXP1 a crucial and highly undervalued regulator of T-cell homeostasis. In this review, we discuss the biology of FOXP1 with a focus on discoveries made in T-cells in recent years.
PubMed 36268015
DOI 10.3389/fimmu.2022.971045
Crossref 10.3389/fimmu.2022.971045