{"entity": "publication", "iuid": "d865df2aba4a427ab8fcb3e3677d8334", "timestamp": "2026-08-22T07:47:31.560Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d865df2aba4a427ab8fcb3e3677d8334.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d865df2aba4a427ab8fcb3e3677d8334"}}, "title": "Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion.", "authors": [{"family": "Kaminskiy", "given": "Yaroslav", "initials": "Y"}, {"family": "Kuznetsova", "given": "Varvara", "initials": "V"}, {"family": "Kudriaeva", "given": "Anna", "initials": "A"}, {"family": "Zmievskaya", "given": "Ekaterina", "initials": "E"}, {"family": "Bulatov", "given": "Emil", "initials": "E"}], "type": "journal article", "published": "2022-10-04", "journal": {"title": "Front Immunol", "issn": "1664-3224", "volume": "13", "pages": "971045", "issn-l": "1664-3224"}, "abstract": "FOXP1 is ubiquitously expressed in the human body and is implicated in both physiological and pathological processes including cancer. However, despite its importance the role of FOXP1 in T-cells has not been extensively studied. Although relatively few phenotypic and mechanistic details are available, FOXP1 role in T-cell quiescence and differentiation of CD4+ subsets has recently been established. FOXP1 prevents spontaneous T-cell activation, preserves memory potential, and regulates the development of follicular helper and regulatory T-cells. Moreover, there is growing evidence that FOXP1 also regulates T-cell exhaustion. Altogether this makes FOXP1 a crucial and highly undervalued regulator of T-cell homeostasis. In this review, we discuss the biology of FOXP1 with a focus on discoveries made in T-cells in recent years.", "doi": "10.3389/fimmu.2022.971045", "pmid": "36268015", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9576946"}], "notes": [], "created": "2026-08-21T12:59:00.481Z", "modified": "2026-08-21T12:59:00.510Z"}