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Zhang L, Dimberg A
Mol Cell Oncol 3 (6) e1141087 [2016-02-18; online 2016-02-18]
In a recent report by Zhang et al., pleiotrophin (PTN) was demonstrated to enhance glioma growth by promoting vascular abnormalization. PTN stimulates glioma vessels through anaplastic lymphoma kinase (Alk)-mediated perivascular deposition of vascular endothelial growth factor (VEGF). Targeting of Alk or VEGF signaling normalizes tumor vessels in PTN-expressing tumors.
PubMed 28090572
DOI 10.1080/23723556.2016.1141087
Crossref 10.1080/23723556.2016.1141087
pmc: PMC5160416
pii: 1141087