{"entity": "publication", "iuid": "cdb5b1a72f7c489197126f38ed9a948c", "timestamp": "2026-08-20T20:33:10.093Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/cdb5b1a72f7c489197126f38ed9a948c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/cdb5b1a72f7c489197126f38ed9a948c"}}, "title": "Pleiotrophin is a driver of vascular abnormalization in glioblastoma.", "authors": [{"family": "Zhang", "given": "Lei", "initials": "L"}, {"family": "Dimberg", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2016-02-18", "journal": {"title": "Mol Cell Oncol", "issn": "2372-3556", "volume": "3", "issue": "6", "pages": "e1141087", "issn-l": null}, "abstract": "In a recent report by Zhang et al., pleiotrophin (PTN) was demonstrated to enhance glioma growth by promoting vascular abnormalization. PTN stimulates glioma vessels through anaplastic lymphoma kinase (Alk)-mediated perivascular deposition of vascular endothelial growth factor (VEGF). Targeting of Alk or VEGF signaling normalizes tumor vessels in PTN-expressing tumors.", "doi": "10.1080/23723556.2016.1141087", "pmid": "28090572", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5160416"}, {"db": "pii", "key": "1141087"}], "notes": [], "created": "2026-08-20T09:37:42.682Z", "modified": "2026-08-20T09:37:42.749Z"}