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Rask-Andersen M, Ivansson E, Höglund J, Ek WE, Karlsson T, Johansson Å
Cancer Cell 41 (6) 1186-1197.e4 [2023-06-12; online 2023-06-14]
Obesity is associated with several types of cancer and fat distribution, which differs dramatically between sexes, has been suggested to be an independent risk factor. However, sex-specific effects on cancer risk have rarely been studied. Here we estimate the effects of fat accumulation and distribution on cancer risk in females and males. We performed a prospective study in 442,519 UK Biobank participants, for 19 cancer types and additional histological subtypes, with a mean follow-up time of 13.4 years. Cox proportional hazard models were used to estimate the effect of 14 different adiposity phenotypes on cancer rates, and a 5% false discovery rate was considered statistically significant. Adiposity-related traits are associated with all but three cancer types, and fat accumulation is associated with a larger number of cancers compared to fat distribution. In addition, fat accumulation or distribution exhibit differential effects between sexes on colorectal, esophageal, and liver cancer.
PubMed 37311415
DOI 10.1016/j.ccell.2023.05.010
Crossref 10.1016/j.ccell.2023.05.010
pii: S1535-6108(23)00177-0