{"entity": "publication", "iuid": "90123417506f40ec8525f4ac3ad1cb99", "timestamp": "2026-09-08T10:05:41.114Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/90123417506f40ec8525f4ac3ad1cb99.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/90123417506f40ec8525f4ac3ad1cb99"}}, "title": "Adiposity and sex-specific cancer risk.", "authors": [{"family": "Rask-Andersen", "given": "Mathias", "initials": "M"}, {"family": "Ivansson", "given": "Emma", "initials": "E"}, {"family": "H\u00f6glund", "given": "Julia", "initials": "J"}, {"family": "Ek", "given": "Weronica E", "initials": "WE"}, {"family": "Karlsson", "given": "Torgny", "initials": "T"}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5"}], "type": "journal article", "published": "2023-06-12", "journal": {"title": "Cancer Cell", "issn": "1878-3686", "volume": "41", "issue": "6", "pages": "1186-1197.e4", "issn-l": "1535-6108"}, "abstract": "Obesity is associated with several types of cancer and fat distribution, which differs dramatically between sexes, has been suggested to be an independent risk factor. However, sex-specific effects on cancer risk have rarely been studied. Here we estimate the effects of fat accumulation and distribution on cancer risk in females and males. We performed a prospective study in 442,519 UK Biobank participants, for 19 cancer types and additional histological subtypes, with a mean follow-up time of 13.4 years. Cox proportional hazard models were used to estimate the effect of 14 different adiposity phenotypes on cancer rates, and a 5% false discovery rate was considered statistically significant. Adiposity-related traits are associated with all but three cancer types, and fat accumulation is associated with a larger number of cancers compared to fat distribution. In addition, fat accumulation or distribution exhibit differential effects between sexes on colorectal, esophageal, and liver cancer.", "doi": "10.1016/j.ccell.2023.05.010", "pmid": "37311415", "labels": [], "xrefs": [{"db": "pii", "key": "S1535-6108(23)00177-0"}], "notes": [], "created": "2026-08-20T06:49:59.088Z", "modified": "2026-08-20T06:49:59.124Z"}