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Chetty LC, Kruger HG, Arvidsson PI, Maguire GEM, Govender T, Naicker T
ACS Omega 9 (35) 37155-37162 [2024-09-03; online 2024-08-22]
This study introduces a novel proline-catalyzed oxidation system employing hydrogen peroxide to synthesize quinones from a diverse range of substrates, including hydroquinones, phenols, resorcinols, aldehydes, and polycyclic aromatics. This approach is well-aligned with green chemistry principles, offering a more environmentally benign approach than earlier studies. Notably, this approach uses cost-effective reagents, proline as a readily available organocatalyst, reduced equivalents of H2O2, metal-free conditions, and notably short reaction times to achieve moderate-to-high yields. This promising approach encourages further exploration of the H2O2-proline system in oxidation reactions. This study's innovative approach and good results set a strong foundation for future research to expand the scope and efficiency of green oxidation processes.
PubMed 39246484
DOI 10.1021/acsomega.4c04383
Crossref 10.1021/acsomega.4c04383