PathwAX II: network-based pathway analysis with interactive visualization of network crosstalk.

Ogris C, Castresana-Aguirre M, Sonnhammer ELL

Bioinformatics 38 (9) 2659-2660 [2022-04-28; online 2022-03-11]

Pathway annotation tools are indispensable for the interpretation of a wide range of experiments in life sciences. Network-based algorithms have recently been developed which are more sensitive than traditional overlap-based algorithms, but there is still a lack of good online tools for network-based pathway analysis. We present PathwAX II-a pathway analysis web tool based on network crosstalk analysis using the BinoX algorithm. It offers several new features compared with the first version, including interactive graphical network visualization of the crosstalk between a query gene set and an enriched pathway, and the addition of Reactome pathways. PathwAX II is available at http://pathwax.sbc.su.se. Supplementary data are available at Bioinformatics online.

PubMed 35266519

DOI 10.1093/bioinformatics/btac153

Crossref 10.1093/bioinformatics/btac153

pmc: PMC9048662
pii: 6546284