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Suryo Rahmanto A, Swartling FJ, Sangfelt O
Mol Cell Oncol 4 (1) e1252871 [2016-11-08; online 2016-11-08]
Cancer cells with stem-like properties are believed to contribute to treatment resistance, dissemination, and recurrence. SOX9 controls stem cell plasticity and its deregulation may provide a basis for tumor progression. Here, we summarize our findings of targeted SOX9 destruction by SCFFBW7 (Skp1/Cul1/F-box) in medulloblastoma and its potential for therapeutic intervention.
PubMed 28197531
DOI 10.1080/23723556.2016.1252871
Crossref 10.1080/23723556.2016.1252871
pmc: PMC5286959
pii: 1252871