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Venkatesan S, Angelova M, Bartkova J, Bakhoum SF, Bartek J, Kanu N, Swanton C
Mol Cell Oncol 10 (1) 2014734 [2022-01-03; online 2022-01-03]
Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor heterogeneity prior to invasion, providing a substrate for cancer evolution.
PubMed 38116246
DOI 10.1080/23723556.2021.2014734
Crossref 10.1080/23723556.2021.2014734
pmc: PMC10730158
pii: 2014734