{"entity": "publication", "iuid": "59b537525af446bb8a9a2fc05ad3f9db", "timestamp": "2026-08-20T20:38:55.400Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/59b537525af446bb8a9a2fc05ad3f9db.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/59b537525af446bb8a9a2fc05ad3f9db"}}, "title": "APOBEC3 as a driver of genetic intratumor heterogeneity.", "authors": [{"family": "Venkatesan", "given": "Subramanian", "initials": "S", "orcid": "0000-0001-6454-8508", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ecacc5d56e504429823daac1d5ea2aeb.json"}}, {"family": "Angelova", "given": "Mihaela", "initials": "M"}, {"family": "Bartkova", "given": "Jirina", "initials": "J"}, {"family": "Bakhoum", "given": "Samuel F", "initials": "SF"}, {"family": "Bartek", "given": "Jiri", "initials": "J"}, {"family": "Kanu", "given": "Nnennaya", "initials": "N"}, {"family": "Swanton", "given": "Charles", "initials": "C"}], "type": "journal article", "published": "2022-01-03", "journal": {"title": "Mol Cell Oncol", "issn": "2372-3556", "volume": "10", "issue": "1", "pages": "2014734", "issn-l": null}, "abstract": "Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor heterogeneity prior to invasion, providing a substrate for cancer evolution.", "doi": "10.1080/23723556.2021.2014734", "pmid": "38116246", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10730158"}, {"db": "pii", "key": "2014734"}], "notes": [], "created": "2026-08-20T09:37:52.812Z", "modified": "2026-08-20T09:37:52.873Z"}