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Vašíček J, Kuznetsova KG, Skiadopoulou D, Unger L, Chera S, Ghila LM, Bandeira N, Njølstad PR, Johansson S, Bruckner S, Käll L, Vaudel M
Nat. Methods 22 (2) 273-277 [2025-02-00; online 2024-12-09]
Amid the advances in genomics, the availability of large reference panels of human haplotypes is key to account for human diversity within and across populations. However, mass spectrometry-based proteomics does not benefit from this information. To address this gap, we introduce ProHap, a Python-based tool that constructs protein sequence databases from phased genotypes of reference panels. ProHap enables researchers to account for haplotype diversity in proteomic searches.
PubMed 39653819
DOI 10.1038/s41592-024-02506-0
Crossref 10.1038/s41592-024-02506-0
pii: 10.1038/s41592-024-02506-0