{"entity": "publication", "iuid": "44870a114cd24900baccd4796b422a86", "timestamp": "2026-08-20T20:40:03.415Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/44870a114cd24900baccd4796b422a86.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/44870a114cd24900baccd4796b422a86"}}, "title": "ProHap enables human proteomic database generation accounting for population diversity.", "authors": [{"family": "Va\u0161\u00ed\u010dek", "given": "Jakub", "initials": "J", "orcid": "0000-0003-2340-0560", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/da1faf367e5c42028b5ecdde0f346b46.json"}}, {"family": "Kuznetsova", "given": "Ksenia G", "initials": "KG", "orcid": "0000-0001-7447-4047", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a07e1c078c64e019aaac124b238877c.json"}}, {"family": "Skiadopoulou", "given": "Dafni", "initials": "D", "orcid": "0000-0001-5572-0070", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1875dd41dae84e64813089daa83138c6.json"}}, {"family": "Unger", "given": "Lucas", "initials": "L"}, {"family": "Chera", "given": "Simona", "initials": "S", "orcid": "0000-0001-6310-3486", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2bbfcb7c2c8545ef923a005dd39ac44f.json"}}, {"family": "Ghila", "given": "Luiza M", "initials": "LM", "orcid": "0000-0001-7173-6312", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad5fb83952714f2c9ee454a34af3270f.json"}}, {"family": "Bandeira", "given": "Nuno", "initials": "N", "orcid": "0000-0001-8385-3655", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ef3073f45c14b7291348f2257d503b8.json"}}, {"family": "Nj\u00f8lstad", "given": "P\u00e5l R", "initials": "PR", "orcid": "0000-0003-0304-6728", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f9b2ded531b4e728c808c7dad460489.json"}}, {"family": "Johansson", "given": "Stefan", "initials": "S", "orcid": "0000-0002-2298-7008", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0e5286d7375241e685d8eab789a3c1de.json"}}, {"family": "Bruckner", "given": "Stefan", "initials": "S", "orcid": "0000-0002-0885-8402", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6985e8b619de452d8022809ef7c7df6a.json"}}, {"family": "K\u00e4ll", "given": "Lukas", "initials": "L", "orcid": "0000-0001-5689-9797", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b4464f2bf868498fa6d149a4a6d60e8b.json"}}, {"family": "Vaudel", "given": "Marc", "initials": "M", "orcid": "0000-0003-1179-9578", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2596035e48ab48c6a100c6ef81757b4f.json"}}], "type": "journal article", "published": "2025-02-00", "journal": {"title": "Nat. Methods", "issn": "1548-7105", "volume": "22", "issue": "2", "pages": "273-277", "issn-l": "1548-7091"}, "abstract": "Amid the advances in genomics, the availability of large reference panels of human haplotypes is key to account for human diversity within and across populations. However, mass spectrometry-based proteomics does not benefit from this information. To address this gap, we introduce ProHap, a Python-based tool that constructs protein sequence databases from phased genotypes of reference panels. ProHap enables researchers to account for haplotype diversity in proteomic searches.", "doi": "10.1038/s41592-024-02506-0", "pmid": "39653819", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s41592-024-02506-0"}], "notes": [], "created": "2026-08-20T09:03:16.989Z", "modified": "2026-08-20T09:03:17.367Z"}