Clinical and functional impact of recurrent S1PR1 mutations in mantle cell lymphoma.

Wasik AM, Wu C, Mansouri L, Rosenquist R, Pan-Hammarström Q, Sander B

Blood Adv 2 (6) 621-625 [2018-03-27; online 2018-03-20]

S1PR1 mutations are present in 7.8% of patients with MCL and are significantly more frequent at relapse. S1PR1 mutations reduce expression of the S1PR1 receptor, which mediates migration towards the tissue-to-blood egress factor S1P in MCL. .

PubMed 29549086

DOI 10.1182/bloodadvances.2017014860

Crossref 10.1182/bloodadvances.2017014860

pmc: PMC5873236
pii: bloodadvances.2017014860


Publications 9.5.1