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Barbera S, Dimberg A, Essand M
Trends Immunol. 46 (10) 677-689 [2025-10-00; online 2025-08-14]
T cells can exchange parts of their plasma membrane along with membrane-associated proteins through trogocytosis. During trogocytosis only certain subsets of membrane-associated proteins seem to be exchanged suggesting a fine-tuned mechanism regulating the selection of what can be transferred. In this review, we describe potential models of trogocytosis and discuss mechanisms that could regulate this process in T cells. Additionally, we delve into how exchanged proteins polarize on the surface of recipient cells, discuss how trogocytosis allows T cells to acquire new functions, and summarize ways to modulate this process in T cells. Understanding trogocytosis can help us better understand the immune response and develop more effective immunotherapies.
PubMed 40816969
DOI 10.1016/j.it.2025.07.008
Crossref 10.1016/j.it.2025.07.008
pii: S1471-4906(25)00175-9