Antimicrobial Dihydroflavonols and Isoflavans Isolated from the Root Bark of Dalbergia gloveri.
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Kiganda I, Wieske LHE, Nchiozem-Ngnitedem VA, Chalo D, Umereweneza D, Ndakala A, Herrebout W, Xiong R, Karpiński TM, Yenesew A, Erdelyi M
J Nat Prod 87 (9) 2263-2271 [2024-09-27; online 2024-09-10]
Three new dihydroflavonols, gloverinols A-C (1-3), a new flavon-3-ol, gloverinol D (4), two new isoflavans, gloveriflavan A (5) and B (6), and seven known compounds were isolated from the root bark of Dalbergia gloveri. The structures of the isolates were elucidated by using NMR, ECD, and HRESIMS data analyses. Among the isolated compounds, gloverinol B (2), gloveriflavan B (6), and 1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4-hydroxyphenyl)-1-propanone (10) were the most active against Staphylococcus aureus, with MIC values of 9.2, 18.4, and 14.2 μM, respectively.
PubMed 39255387
DOI 10.1021/acs.jnatprod.4c00690
Crossref 10.1021/acs.jnatprod.4c00690