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ten Dijke P, van Dam H
Cancer Cell 27 (2) 151-153 [2015-02-09; online 2015-02-12]
TGF-β/SMAD signaling has long been known to exhibit a dual role in cancer, questioning what determines its context-dependent functions. In this issue of Cancer Cell, Xu and colleagues describe a critical role of the adaptor protein 14-3-3ζ in modulating SMAD activities by changing its interaction partners during breast cancer progression.
PubMed 25670073
DOI 10.1016/j.ccell.2015.01.005
Crossref 10.1016/j.ccell.2015.01.005
pii: S1535-6108(15)00020-3