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Moustakas A, Heldin CH
Mol. Cell 51 (5) 555-556 [2013-09-12; online 2013-09-17]
In this issue, Zhang et al. (2013) demonstrate that the ubiquitin ligase TRAF4 associates with the TGF-β receptors, rescuing them from degradation and ubiquitylating TAK1 to activate non-Smad signaling, which together promote metastasis of breast cancer cells.
PubMed 24034692
DOI 10.1016/j.molcel.2013.08.034
Crossref 10.1016/j.molcel.2013.08.034
pii: S1097-2765(13)00634-5