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Sobocki BK, Basset CA, Bruhn-Olszewska B, Olszewski P, Szot O, Kaźmierczak-Siedlecka K, Guziak M, Nibali L, Leone A
Int J Mol Sci 23 (2) - [2022-01-16; online 2022-01-16]
Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has been recently associated with an increased risk of cancer. While information about the topic remains somewhat scarce, a deeper understanding of the underlying mechanistic pathways promoting neoplasia in periodontitis patients is of fundamental importance. This manuscript presents the literature as well as a panel of tables and figures on the molecular mechanisms of Porphyromonas gingivalis and Fusobacterium nucleatum, two main oral pathogens in periodontitis pathology, involved in instigating tumorigenesis. We also present evidence for potential links between the RANKL-RANK signaling axis as well as circulating cytokines/leukocytes and carcinogenesis. Due to the nonconclusive data associating periodontitis and cancer reported in the case and cohort studies, we examine clinical trials relevant to the topic and summarize their outcome.
PubMed 35055157
DOI 10.3390/ijms23020970
Crossref 10.3390/ijms23020970
pmc: PMC8778447
pii: ijms23020970