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Mi J, Ren L, Andersson O
Trends in molecular medicine 30 (10) 932-949 [2024-10-00; online 2024-06-01]
The zebrafish has become an outstanding model for studying organ development and tissue regeneration, which is prominently leveraged for studies of pancreatic development, insulin-producing β-cells, and diabetes. Although studied for more than two decades, many aspects remain elusive and it has only recently been possible to investigate these due to technical advances in transcriptomics, chemical-genetics, genome editing, drug screening, and in vivo imaging. Here, we review recent findings on zebrafish pancreas development, β-cell regeneration, and how zebrafish can be used to provide novel insights into gene functions, disease mechanisms, and therapeutic targets in diabetes, inspiring further use of zebrafish for the development of novel therapies for diabetes.
PubMed 38825440
DOI 10.1016/j.molmed.2024.05.002
Crossref 10.1016/j.molmed.2024.05.002
pii: S1471-4914(24)00124-2