Tumor-induced neutrophil extracellular traps-drivers of systemic inflammation and vascular dysfunction.

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Cedervall J, Dimberg A, Olsson AK

Oncoimmunology 5 (3) e1098803 [2016-03-00; online 2015-10-29]

Neutrophil extracellular traps (NETs) are part of the innate immune defense against microbes, but their contribution to several non-infectious inflammatory conditions has recently been unraveled. We demonstrate that NETs accumulate in the peripheral circulation in tumor-bearing mice, causing systemic inflammation and vascular dysfuntion in organs not affected by tumor cells.

PubMed 27141360

DOI 10.1080/2162402X.2015.1098803

Crossref 10.1080/2162402X.2015.1098803

pmc: PMC4839319
pii: 1098803