Lipid radicals cause light-induced retinal degeneration.

Enoki M, Shinto S, Matsuoka Y, Otsuka A, Kaidzu S, Tanito M, Shibata T, Uchida K, Ohira A, Yamato M, Yamada KI

Chem. Commun. (Camb.) 53 (79) 10922-10925 [2017-10-03; online 2017-09-21]

Age-related macular degeneration (AMD) is the leading cause of blindness worldwide. Although the cause of AMD remains unknown, lipid peroxidation (LPO) end-products are critical molecules for its development. Herein, we report the imaging of lipid radicals, which are key factors in the LPO reaction, and therapeutic information using animal models.

PubMed 28930310

DOI 10.1039/c7cc03387g

Crossref 10.1039/c7cc03387g


Publications 9.5.1