Local, calcium- and reward-based synaptic learning rule that enhances dendritic nonlinearities can solve the nonlinear feature binding problem.

Khodadadi Z, Trpevski D, Lindroos R, Hellgren Kotaleski J

Elife 13 (-) - [2025-11-17; online 2025-11-17]

This study investigates the computational potential of single striatal projection neurons (SPNs), emphasizing dendritic nonlinearities and their crucial role in solving complex integration problems. Utilizing a biophysically detailed multicompartmental model of an SPN, we introduce a calcium-based, local synaptic learning rule dependent on dendritic plateau potentials. According to what is known about excitatory corticostriatal synapses, the learning rule is governed by local calcium dynamics from NMDA and L-type calcium channels and dopaminergic reward signals. In order to devise a self-adjusting learning rule, which ensures stability for individual synaptic weights, metaplasticity is also used. We demonstrate that this rule allows single neurons with sufficiently nonlinear dendrites to solve the nonlinear feature binding problem, a task traditionally attributed to neuronal networks. We also detail an inhibitory plasticity mechanism that contributes to dendritic compartmentalization, further enhancing computational efficiency in dendrites. This in silico study highlights the computational potential of single neurons, providing deeper insights into neuronal information processing and the mechanisms by which the brain executes complex computations.

PubMed 41247161

DOI 10.7554/eLife.97274

Crossref 10.7554/eLife.97274

pmc: PMC12622965
pii: 97274