Spatial transcriptomics of human placentas reveal distinct RNA patterns associated with morphology and preeclampsia.

Bhalla N, Franzén L, Scheynius A, Papadogiannakis N, Hansson SR, Lager S, Ståhl PL

Placenta 139 (-) 213-216 [2023-08-00; online 2023-07-05]

Spatial transcriptomics (ST) maps RNA level patterns within a tissue. This technology has not been previously applied to human placental tissue. We demonstrate analysis of human placental samples with ST. Unsupervised clustering revealed that distinct RNA patterns were found corresponding to different morphological structures. Additionally, when focusing upon terminal villi and hemoglobin associated structures, RNA levels differed between placentas from full term healthy pregnancies and those complicated by preeclampsia. The results from this study can provide a benchmark for future ST studies in placenta.

PubMed 37481829

DOI 10.1016/j.placenta.2023.07.004

Crossref 10.1016/j.placenta.2023.07.004

pii: S0143-4004(23)00154-6