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Chua KJ, Quilang RC, Sallinger K, Aktipis CA, Arck P, Bianchi DW, Chang HD, Cleaves HJ, Eikmans M, Fjeldstad HES, Haig D, Harrington WE, Horsnell W, Jacobsen DP, Kamper-Jørgensen M, Kanaan SB, Khosrotehrani K, Lambert NC, Nelson JL, Olsen MB, Pan TD, Prins JR, Schildberg FA, Staff AC, Ståhlberg A, Stelzer IA, Urbschat C, Way SS, Wilson MA, Ye J, Kroneis T, Boddy AM
Adv Sci (Weinh) 12 (48) e14969 [2025-12-00; online 2025-10-24]
Microchimerism research has recently gained renewed attention despite known existence of these rare cells for decades. Fetal and maternal microchimeric-derived cells may have functional capabilities, and are increasingly associated with both beneficial and adverse health outcomes. Yet, establishing the role of microchimerism in health has been largely constrained methodologically and theoretically. The Microchimerism, Human Health, and Evolution Project address these challenges by calling on 29 leading microchimerism experts to put forth key research questions that can substantially advance the field. Seven major categories are identified: function and mechanism; microchimerism in interventions, treatment, and transplant; mapping "generational microchimerism"; evolution; microchimerism detection; appropriate experimental model systems; and definition of microchimerism. Identifying these questions - and continuing to find answers - will be crucial for advancing the knowledge of microchimerism in health and disease.
PubMed 41134118
DOI 10.1002/advs.202514969
Crossref 10.1002/advs.202514969