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Das S, Doñas C, Akeus P, Quiding-Järbrink M, Mora JR, Villablanca EJ
PLoS ONE 13 (9) e0204181 [2018-09-20; online 2018-09-20]
The gut homing receptor integrin α4β7 is essential for the migration of pro-inflammatory T cells into the gut mucosa. Since intestinal neoplasia has been associated with chronic inflammation, we investigated whether interfering with gut-homing affects intestinal tumorigenesis. Using chemically induced and spontaneous intestinal tumor models we showed that lack of β7 integrin significantly impairs tumor growth without affecting tumor frequencies, with a mild translatable effect on overall survival. This correlates with human data showing lower MAdCAM-1 expression and disease-free survival in colorectal cancer patients. Thus, paradoxically in contrast to extra-intestinal tumors, blocking migration of immune cells into the gut might have a positive therapeutic effect on intestinal neoplasia.
PubMed 30235302
DOI 10.1371/journal.pone.0204181
Crossref 10.1371/journal.pone.0204181
pmc: PMC6147474
pii: PONE-D-18-19194