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Elf J
Cell Systems 3 (4) 325-327 [2016-10-26; online 2016-10-28]
It is not known how a cell manages to find a specific DNA sequence sufficiently fast to repair a broken chromosome through homologous recombination. I propose a solution based on freely diffusing molecules that are programmed with sequences corresponding to those flanking the break site. In such a process, the target search would be parallelized.
PubMed 27788356
DOI 10.1016/j.cels.2016.10.005
Crossref 10.1016/j.cels.2016.10.005
pii: S2405-4712(16)30324-6