Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor -BB in an Erk1/2-, STAT3- and p53-dependent manner.

Yin R, Eger G, Sarri N, Rorsman C, Heldin CH, Lennartsson J

Biochem. Biophys. Res. Commun. 519 (3) 469-474 [2019-11-12; online 2019-09-13]

Dual specificity phosphatase (DUSP) 4 has been described as a negative regulator of MAP kinase signaling, in particular for the ERK1/2 and JNK pathways. We found that DUSP4 expression was upregulated in response to prolonged platelet-derived growth factor (PDGF)-BB stimulation. The PDGF-BB-induced DUSP4 expression was dependent on ERK1/2, STAT3 and p53. We found that inhibition of ERK1/2 effectively reduced DUSP4 mRNA levels, whereas STAT3 was necessary for maintaining p53 expression. p53 has binding sites in the DUSP4 promoter and was found to promote DUSP4 expression.

PubMed 31526568

DOI 10.1016/j.bbrc.2019.09.014

Crossref 10.1016/j.bbrc.2019.09.014

pii: S0006-291X(19)31735-8