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Zheng D, Williams C, Vold JA, Nguyen JH, Harnois DM, Bagaria SP, McLaughlin SA, Li Z
Cancer Lett. 438 (-) 24-31 [2018-12-01; online 2018-09-14]
Gender differences in the incidences of cancers have been found in almost all human cancers. However, the mechanisms that underlie gender disparities in most human cancer types have been under-investigated. Here, we provide a comprehensive overview of potential mechanisms underlying sexual dimorphism of each cancer regarding sex hormone signaling. Fully addressing the mechanisms of sexual dimorphism in human cancers will greatly benefit current development of precision medicine. Our discussions of potential mechanisms underlying sexual dimorphism in each cancer will be instructive for future cancer research on gender disparities.
PubMed 30223066
DOI 10.1016/j.canlet.2018.09.001
Crossref 10.1016/j.canlet.2018.09.001
mid: NIHMS1506724
pmc: PMC6287770
pii: S0304-3835(18)30553-6