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Khumalo MF, Akpan ED, Chinthakindi PK, Brasil EM, Rajbongshi KK, Makatini MM, Govender T, Kruger HG, Naicker T, Arvidsson PI
RSC Adv. 8 (65) 37503-37507 [2018-11-01; online 2018-11-07]
Herein, we report the preparation of 1,2,4-thiadiazinane 1,1-dioxides from reaction of β-aminoethane sulfonamides with dichloromethane, dibromomethane and formaldehyde as methylene donors. The β-aminoethane sulfonamides were obtained through sequential Michael addition of amines to α,β-unsaturated ethenesulfonyl fluorides followed by further DBU mediated sulfur(vi) fluoride exchange (SuFEx) reaction with amines at the S-F bond.
PubMed 35557800
DOI 10.1039/c8ra07627h
Crossref 10.1039/c8ra07627h
pmc: PMC9089429
pii: c8ra07627h