β-Carboline-based light and pH dual stimuli-responsive ion transporters induce cancer cell death.

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Kar MK, Mahata R, Srimayee S, Haloi N, Kumar R, Lindahl E, Santra MK, Manna D

Chem. Commun. (Camb.) 60 (64) 8419-8422 [2024-08-06; online 2024-08-06]

Light and pH dual-responsive ion transporters offer better applicability for cancer due to higher tunability and low cytotoxicity. Herein, we demonstrate the development of pH-responsive β-carboline-based ionophores and photocleavable-linker appended β-carboline-based proionophores to facilitate the controlled transport of Cl- across membranes, leading to apoptotic and autophagic cancer cell death.

PubMed 39028297

DOI 10.1039/d4cc02232g

Crossref 10.1039/d4cc02232g