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Codeluppi S, Borm LE, Zeisel A, La Manno G, van Lunteren JA, Svensson CI, Linnarsson S
Nat. Methods 15 (11) 932-935 [2018-11-00; online 2018-10-30]
Global efforts to create a molecular census of the brain using single-cell transcriptomics are producing a large catalog of molecularly defined cell types. However, spatial information is lacking and new methods are needed to map a large number of cell type-specific markers simultaneously on large tissue areas. Here, we describe a cyclic single-molecule fluorescence in situ hybridization methodology and define the cellular organization of the somatosensory cortex.
PubMed 30377364
DOI 10.1038/s41592-018-0175-z
Crossref 10.1038/s41592-018-0175-z
pii: 10.1038/s41592-018-0175-z