{"entity": "researcher", "timestamp": "2026-08-23T22:03:18.281Z", "family": "Day", "given": "Felix R", "initials": "FR", "orcid": "0000-0003-3789-7651", "affiliations": ["Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe6d8429149d41ac9130ad3b80414bcb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe6d8429149d41ac9130ad3b80414bcb"}}, "publications": [{"entity": "publication", "iuid": "4a11d8a1ea834246992df5257ef123e0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4a11d8a1ea834246992df5257ef123e0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4a11d8a1ea834246992df5257ef123e0"}}, "title": "Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.", "authors": [{"family": "Mills", "given": "Melinda C", "initials": "MC", "orcid": "0000-0003-1704-0001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/78515e421046451c983d115b9bc4adfc.json"}}, {"family": "Tropf", "given": "Felix C", "initials": "FC", "orcid": "0000-0003-2445-515X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4312fccc5cc04b9a9e456c32e1284bc1.json"}}, {"family": "Brazel", "given": "David M", "initials": "DM", "orcid": "0000-0001-5361-2498", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8bfbb87d00b442abb7075761a261861e.json"}}, {"family": "van Zuydam", "given": "Natalie", "initials": "N"}, {"family": "Vaez", "given": "Ahmad", "initials": "A", "orcid": "0000-0001-9048-3795", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a21fe8c196dc4c5db0714d26d698f98d.json"}}, {"family": "eQTLGen Consortium", "given": "", "initials": ""}, {"family": "BIOS Consortium", "given": "", "initials": ""}, {"family": "Human Reproductive Behaviour Consortium", "given": "", "initials": ""}, {"family": "Pers", "given": "Tune H", "initials": "TH", "orcid": "0000-0003-0207-4831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5229243d3ee54140b73924a3c221ecf1.json"}}, {"family": "Snieder", "given": "Harold", "initials": "H", "orcid": "0000-0003-1949-2298", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb5a2135b774429596606e980c9268ec.json"}}, {"family": "Perry", "given": "John R B", "initials": "JRB", "orcid": "0000-0001-6483-3771", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0985df254e574e5e8b7d783256c84ed7.json"}}, {"family": "Ong", "given": "Ken K", "initials": "KK", "orcid": "0000-0003-4689-7530", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2fc9a3caa450429e9fe6b6dbeb5f0a44.json"}}, {"family": "den Hoed", "given": "Marcel", "initials": "M", "orcid": "0000-0001-8081-428X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1d3e34c06cff4446ad703cde901c5033.json"}}, {"family": "Barban", "given": "Nicola", "initials": "N", "orcid": "0000-0002-4362-4652", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc798207bae5429ba3f0d4c92cbab4e8.json"}}, {"family": "Day", "given": "Felix R", "initials": "FR", "orcid": "0000-0003-3789-7651", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe6d8429149d41ac9130ad3b80414bcb.json"}}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "Nat Hum Behav", "issn": "2397-3374", "volume": "5", "issue": "12", "pages": "1717-1730", "issn-l": null}, "abstract": "Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with a 5-6% polygenic score prediction. Heritability of age at first birth shifted from 9% [CI = 4-14%] for women born in 1940 to 22% [CI = 19-25%] for those born in 1965. Signals are driven by the genetics of reproductive biology and externalising behaviour, with key genes related to follicle stimulating hormone (FSHB), implantation (ESR1), infertility and spermatid differentiation. Our findings suggest that polycystic ovarian syndrome may lead to later age at first birth, linking with infertility. Late age at first birth is associated with parental longevity and reduced incidence of type 2 diabetes and cardiovascular disease. Higher childhood socioeconomic circumstances and those in the highest polygenic score decile (90%+) experience markedly later reproductive onset. Results are relevant for improving teenage and late-life health, understanding longevity and guiding experimentation into mechanisms of infertility.", "doi": "10.1038/s41562-021-01135-3", "pmid": "34211149", "labels": [], "xrefs": [{"db": "mid", "key": "EMS124573"}, {"db": "pmc", "key": "PMC7612120"}, {"db": "pii", "key": "10.1038/s41562-021-01135-3"}], "notes": [], "created": "2026-08-21T11:50:31.213Z", "modified": "2026-08-21T11:50:31.531Z"}, {"entity": "publication", "iuid": "9671e8b30b7441709b67610e9b5985eb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9671e8b30b7441709b67610e9b5985eb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9671e8b30b7441709b67610e9b5985eb"}}, "title": "Quality control and conduct of genome-wide association meta-analyses.", "authors": [{"family": "Winkler", "given": "Thomas W", "initials": "TW"}, {"family": "Day", "given": "Felix R", "initials": "FR", "orcid": "0000-0003-3789-7651", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe6d8429149d41ac9130ad3b80414bcb.json"}}, {"family": "Croteau-Chonka", "given": "Damien C", "initials": "DC"}, {"family": "Wood", "given": "Andrew R", "initials": "AR"}, {"family": "Locke", "given": "Adam E", "initials": "AE"}, {"family": "M\u00e4gi", "given": "Reedik", "initials": "R"}, {"family": "Ferreira", "given": "Teresa", "initials": "T"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Graff", "given": "Mariaelisa", "initials": "M"}, {"family": "Justice", "given": "Anne E", "initials": "AE"}, {"family": "Luan", "given": "Jian'an", "initials": "J"}, {"family": "Gustafsson", "given": "Stefan", "initials": "S"}, {"family": "Randall", "given": "Joshua C", "initials": "JC"}, {"family": "Vedantam", "given": "Sailaja", "initials": "S"}, {"family": "Workalemahu", "given": "Tsegaselassie", "initials": "T"}, {"family": "Kilpel\u00e4inen", "given": "Tuomas O", "initials": "TO"}, {"family": "Scherag", "given": "Andr\u00e9", "initials": "A"}, {"family": "Esko", "given": "Tonu", "initials": "T"}, {"family": "Kutalik", "given": "Zolt\u00e1n", "initials": "Z"}, {"family": "Heid", "given": "Iris M", "initials": "IM"}, {"family": "Loos", "given": "Ruth J F", "initials": "RJ"}, {"family": "Genetic Investigation of Anthropometric Traits (GIANT) Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2014-05-00", "journal": {"title": "Nat Protoc", "issn": "1750-2799", "volume": "9", "issue": "5", "pages": "1192-1212", "issn-l": null}, "abstract": "Rigorous organization and quality control (QC) are necessary to facilitate successful genome-wide association meta-analyses (GWAMAs) of statistics aggregated across multiple genome-wide association studies. This protocol provides guidelines for (i) organizational aspects of GWAMAs, and for (ii) QC at the study file level, the meta-level across studies and the meta-analysis output level. Real-world examples highlight issues experienced and solutions developed by the GIANT Consortium that has conducted meta-analyses including data from 125 studies comprising more than 330,000 individuals. We provide a general protocol for conducting GWAMAs and carrying out QC to minimize errors and to guarantee maximum use of the data. We also include details for the use of a powerful and flexible software package called EasyQC. Precise timings will be greatly influenced by consortium size. For consortia of comparable size to the GIANT Consortium, this protocol takes a minimum of about 10 months to complete.", "doi": "10.1038/nprot.2014.071", "pmid": "24762786", "labels": [], "xrefs": [{"db": "mid", "key": "EMS59293"}, {"db": "pmc", "key": "PMC4083217"}, {"db": "pii", "key": "nprot.2014.071"}], "notes": [], "created": "2018-12-05T08:45:10.571Z", "modified": "2026-08-21T11:46:20.279Z"}]}