{"entity": "researcher", "timestamp": "2026-08-20T21:15:11.600Z", "family": "Shen", "given": "Xia", "initials": "X", "orcid": "0000-0003-4390-1979", "affiliations": ["Biostatistics Group, School of Life Sciences, Sun Yat-sen University, Guangzhou, China. shenx@fudan.edu.cn.", "Center for Intelligent Medicine Research, Greater Bay Area Institute of Precision Medicine (Guangzhou), Fudan University, Guangzhou, China. shenx@fudan.edu.cn.", "Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK. shenx@fudan.edu.cn.", "State Key Laboratory of Genetic Engineering, Center for Evolutionary Biology, School of Life Sciences, Fudan University, Shanghai, China. shenx@fudan.edu.cn.", "Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. shenx@fudan.edu.cn."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/fdf103b9d2464f7ca1ed1a8eb1a5808d.json"}, "display": {"href": 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"orcid": "0000-0003-4803-8633", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/37ba93e5f6b041e4a4bea6a345adfb72.json"}}, {"family": "Zhai", "given": "Ranran", "initials": "R", "orcid": "0000-0002-5834-9120", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0aaae5317db3468384510b9727a07e02.json"}}, {"family": "Timmers", "given": "Paul R H J", "initials": "PRHJ", "orcid": "0000-0002-5197-1267", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1a7fb58cb2f4bd1b48f23be33de0c6e.json"}}, {"family": "Feng", "given": "Xiao", "initials": "X", "orcid": "0000-0001-8919-6000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/038fb589749d475183d682f9c3530026.json"}}, {"family": "Li", "given": "Ting", "initials": "T", "orcid": "0000-0002-9614-1566", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/032f6825c6bb4b1284c3b3cbd95099fc.json"}}, {"family": "Yao", "given": "Yue", "initials": "Y"}, {"family": "Maslov", "given": "Denis", "initials": "D", "orcid": "0000-0003-2806-5933", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8f6b346d03a48bdab23a9b67062935b.json"}}, {"family": "Timoshchuk", "given": "Anna", "initials": "A", "orcid": "0000-0001-8529-4498", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2f9b4737e1f94049bd6ac5a35b02846b.json"}}, {"family": "Tu", "given": "Fengyu", "initials": "F", "orcid": "0000-0001-8748-7250", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f4be639f23e46f8b3940fa080a5b2ac.json"}}, {"family": "Twait", "given": "Emma L", "initials": "EL"}, {"family": "May-Wilson", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-2668-5717", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d39731ddad649e88c6958a9fc03008b.json"}}, {"family": "Muckian", "given": "Marisa 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{"family": "Harris", "given": "Sarah E", "initials": "SE", "orcid": "0000-0002-4941-5106", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4056bf3ecf854b1c8a2189564f6e0ded.json"}}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0003-1422-2993", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/462fd4169f41418887a5a979e0808d87.json"}}, {"family": "G\u00f6teson", "given": "Andreas", "initials": "A", "orcid": "0000-0001-6118-6054", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0969aa99508042e6b508bc528b433d82.json"}}, {"family": "Lagging", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-5692-2755", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cbe502b854d248ddb6119b9e786b8558.json"}}, {"family": "Ikram", "given": "Mohammad Arfan", "initials": "MA", "orcid": "0000-0003-0372-8585", "researcher": {"href": 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"https://publications-affiliated.scilifelab.se/researcher/15fa758fb7d84cd9b38150291f2002b5.json"}}, {"family": "Marioni", "given": "Riccardo E", "initials": "RE", "orcid": "0000-0003-4430-4260", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e9bc46c3aa1b4e379bd2eebd8bb23756.json"}}, {"family": "Enroth", "given": "Stefan", "initials": "S"}, {"family": "Reiner", "given": "Alexander P", "initials": "AP", "orcid": "0000-0002-1427-4470", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/244e81f4f21645e9b66f7b2ba6a8eb07.json"}}, {"family": "Dedoussis", "given": "George", "initials": "G"}, {"family": "Zeggini", "given": "Eleftheria", "initials": "E"}, {"family": "Sharapov", "given": "Sodbo", "initials": "S", "orcid": "0000-0003-0279-4900", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b435f6d60c674f969172aeb5216a24ae.json"}}, {"family": "Aulchenko", "given": "Yurii S", "initials": "YS"}, {"family": "Butterworth", "given": "Adam S", "initials": "AS", "orcid": "0000-0002-6915-9015", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88842023860148bb8d155b5c18db72a8.json"}}, {"family": "M\u00e4larstig", "given": "Anders", "initials": "A", "orcid": "0000-0003-2608-1358", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32b012456e6f490e99b12f5fb1216ce8.json"}}, {"family": "Wilson", "given": "James F", "initials": "JF", "orcid": "0000-0001-5751-9178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513b6983cc9d478ab9d81c2f21579961.json"}}, {"family": "Navarro", "given": "Pau", "initials": "P", "orcid": "0000-0001-5576-8584", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd1c6be37f30445e8d11b73f7ea54099.json"}}, {"family": "Shen", "given": "Xia", "initials": "X", "orcid": "0000-0003-4390-1979", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fdf103b9d2464f7ca1ed1a8eb1a5808d.json"}}], "type": "journal article", "published": "2024-11-00", "journal": {"title": "Nat Hum Behav", "issn": "2397-3374", "volume": "8", "issue": "11", "pages": "2222-2234", "issn-l": null}, "abstract": "Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioural traits and the disease aetiology of neuropsychiatric disorders. Here the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,000 individuals for 184 neuro-related proteins in human plasma. The analysis identified 125 cis-regulatory protein quantitative trait loci (cis-pQTL) and 164 trans-pQTL. The mapped pQTL capture on average 50% of each protein's heritability. At the cis-pQTL, multiple proteins shared a genetic basis with human behavioural traits such as alcohol and food intake, smoking and educational attainment, as well as neurological conditions and psychiatric disorders such as pain, neuroticism and schizophrenia. Integrating with established drug information, the causal inference analysis validated 52 out of 66 matched combinations of protein targets and diseases or side effects with available drugs while suggesting hundreds of repurposing and new therapeutic targets.", "doi": "10.1038/s41562-024-01963-z", "pmid": "39210026", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s41562-024-01963-z"}], "notes": [], "created": "2026-08-20T08:55:14.560Z", "modified": "2026-08-20T08:55:15.594Z"}, {"entity": "publication", "iuid": "47baad2a3dc84380aeef0c6d4cf97660", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/47baad2a3dc84380aeef0c6d4cf97660.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/47baad2a3dc84380aeef0c6d4cf97660"}}, "title": "Unraveling Neuro-Proteogenomic Landscape and Therapeutic Implications for Human Behaviors and Psychiatric Disorders.", "authors": [{"family": "Repetto", "given": "Linda", "initials": "L"}, {"family": "Chen", "given": "Jiantao", "initials": "J"}, {"family": "Yang", "given": "Zhijian", "initials": "Z", "orcid": "0000-0003-4803-8633", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/37ba93e5f6b041e4a4bea6a345adfb72.json"}}, {"family": "Zhai", "given": "Ranran", "initials": "R", "orcid": "0000-0002-5834-9120", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0aaae5317db3468384510b9727a07e02.json"}}, {"family": "Timmers", "given": "Paul R H J", "initials": "PRHJ", "orcid": "0000-0002-5197-1267", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1a7fb58cb2f4bd1b48f23be33de0c6e.json"}}, {"family": "Li", "given": "Ting", "initials": "T", "orcid": "0000-0002-9614-1566", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/032f6825c6bb4b1284c3b3cbd95099fc.json"}}, {"family": "Twait", "given": "Emma L", "initials": "EL"}, {"family": "May-Wilson", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-2668-5717", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d39731ddad649e88c6958a9fc03008b.json"}}, {"family": "Muckian", "given": "Marisa D", "initials": "MD"}, {"family": "Prins", "given": "Bram P", "initials": "BP"}, {"family": "Png", "given": "Grace", "initials": "G"}, {"family": "Kooperberg", "given": "Charles", "initials": "C"}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Hillary", "given": "Robert F", "initials": "RF"}, {"family": "Wheeler", "given": "Eleanor", "initials": "E", "orcid": "0000-0002-8616-6444", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fd1a2d0a53e442aa8900ef0e09b23b3.json"}}, {"family": "Pan", "given": "Lu", "initials": "L"}, {"family": "He", "given": "Yazhou", "initials": "Y"}, {"family": "Klasson", "given": "Sofia", "initials": "S"}, {"family": "Ahmad", "given": "Shahzad", "initials": "S"}, {"family": "Peters", "given": "James E", "initials": "JE"}, {"family": "Gilly", "given": "Arthur", "initials": "A"}, {"family": "Karaleftheri", "given": "Maria", "initials": "M"}, {"family": "Tsafantakis", "given": "Emmanouil", "initials": "E"}, {"family": "Haessler", "given": "Jeffrey", "initials": "J"}, {"family": "Gyllensten", "given": "Ulf", "initials": "U"}, {"family": "Harris", "given": "Sarah E", "initials": "SE", "orcid": "0000-0002-4941-5106", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4056bf3ecf854b1c8a2189564f6e0ded.json"}}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0003-1422-2993", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/462fd4169f41418887a5a979e0808d87.json"}}, {"family": "G\u00f6teson", "given": "Andreas", "initials": "A"}, {"family": "Lagging", "given": "Cecilia", "initials": "C"}, {"family": "Ikram", "given": "Mohammad Arfan", "initials": "MA", "orcid": "0000-0003-0372-8585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef9df12e0e6743f5a97d73c58e75443b.json"}}, {"family": "van Duijn", "given": "Cornelia M", "initials": "CM", "orcid": "0000-0002-2374-9204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f80ecaf200f24b4092c9a6ed77dfff8d.json"}}, {"family": "Jern", "given": "Christina", "initials": "C"}, {"family": "Land\u00e9n", "given": "Mikael", "initials": "M", "orcid": "0000-0002-4496-6451", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e788f5999d644719a8c4816c88d7de3.json"}}, {"family": "Langenberg", "given": "Claudia", "initials": "C", "orcid": "0000-0002-5017-7344", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f287f3248cc24c6cbfc100c249b87418.json"}}, {"family": "Deary", "given": "Ian J", "initials": "IJ", "orcid": "0000-0002-1733-263X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/15fa758fb7d84cd9b38150291f2002b5.json"}}, {"family": "Marioni", "given": "Riccardo E", "initials": "RE", "orcid": "0000-0003-4430-4260", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e9bc46c3aa1b4e379bd2eebd8bb23756.json"}}, {"family": "Enroth", "given": "Stefan", "initials": "S"}, {"family": "Reiner", "given": "Alexander P", "initials": "AP", "orcid": "0000-0002-1427-4470", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/244e81f4f21645e9b66f7b2ba6a8eb07.json"}}, {"family": "Dedoussis", "given": "George", "initials": "G"}, {"family": "Zeggini", "given": "Eleftheria", "initials": "E"}, {"family": "Butterworth", "given": "Adam S", "initials": "AS"}, {"family": "M\u00e4larstig", "given": "Anders", "initials": "A"}, {"family": "Wilson", "given": "James F", "initials": "JF", "orcid": "0000-0001-5751-9178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513b6983cc9d478ab9d81c2f21579961.json"}}, {"family": "Navarro", "given": "Pau", "initials": "P"}, {"family": "Shen", "given": "Xia", "initials": "X", "orcid": "0000-0003-4390-1979", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fdf103b9d2464f7ca1ed1a8eb1a5808d.json"}}], "type": "preprint", "published": "2023-03-31", "journal": {"title": "Res Sq", "issn": "2693-5015", "issn-l": null}, "abstract": "Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioral traits and the disease etiology of neuropsychiatric disorders. Here, the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,500 individuals for 184 neuro-related proteins in human plasma. The analysis identified 117 cis-regulatory protein quantitative trait loci (cis-pQTL) and 166 trans-pQTL. The mapped pQTL capture on average 50% of each protein's heritability. Mendelian randomization analyses revealed multiple proteins showing potential causal effects on neuro-related traits such as sleeping, smoking, feelings, alcohol intake, mental health, and psychiatric disorders. Integrating with established drug information, we validated 13 out of 13 matched combinations of protein targets and diseases or side effects with available drugs, while suggesting hundreds of re-purposing and new therapeutic targets. This consortium effort provides a large-scale proteogenomic resource for biomedical research on human behaviors and other neuro-related phenotypes.", "doi": "10.21203/rs.3.rs-2720355/v1", "pmid": "37034613", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10081382"}, {"db": "pii", "key": "rs.3.rs-2720355"}], "notes": [], "created": "2026-08-20T12:58:55.505Z", "modified": "2026-08-20T12:58:55.704Z"}]}