{"entity": "researcher", "timestamp": "2026-11-14T04:19:53.625Z", "family": "Vajdic", "given": "Claire M", "initials": "CM", "orcid": "0000-0002-3612-8298", "affiliations": ["Centre for Big Data Research in Health, University of New South Wales, Sydney, New South Wales 2052, Australia."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc3e3af04c8a42d18d40304f2688c9f8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc3e3af04c8a42d18d40304f2688c9f8"}}, "publications": [{"entity": "publication", "iuid": "a1b434b73f8b4321a0f5c2b8e7014e69", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a1b434b73f8b4321a0f5c2b8e7014e69.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a1b434b73f8b4321a0f5c2b8e7014e69"}}, "title": "Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.", "authors": [{"family": "Law", "given": "Philip J", "initials": "PJ", "orcid": "0000-0001-9663-4611", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/499974f99dfe4fdd87a73034acb98d3e.json"}}, {"family": "Berndt", "given": "Sonja I", "initials": "SI"}, {"family": "Speedy", "given": "Helen E", "initials": "HE"}, {"family": "Camp", "given": "Nicola J", "initials": "NJ"}, {"family": "Sava", "given": "Georgina P", "initials": "GP"}, {"family": "Skibola", "given": "Christine F", "initials": "CF"}, {"family": "Holroyd", "given": "Amy", "initials": "A"}, {"family": "Joseph", "given": "Vijai", "initials": "V", "orcid": "0000-0002-7933-151X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a056e9c694a14da8a883ac07a4c039c9.json"}}, {"family": "Sunter", "given": "Nicola J", "initials": "NJ"}, {"family": "Nieters", "given": "Alexandra", "initials": "A"}, {"family": "Bea", "given": "Silvia", "initials": "S"}, {"family": "Monnereau", "given": "Alain", "initials": "A"}, {"family": "Martin-Garcia", "given": "David", "initials": "D"}, {"family": "Goldin", "given": "Lynn R", "initials": "LR"}, {"family": "Clot", "given": "Guillem", "initials": "G"}, {"family": "Teras", "given": "Lauren R", "initials": "LR"}, {"family": "Quintela", "given": "In\u00e9s", "initials": "I"}, {"family": "Birmann", "given": "Brenda M", "initials": "BM"}, {"family": "Jayne", "given": "Sandrine", "initials": "S"}, {"family": "Cozen", "given": "Wendy", "initials": "W"}, {"family": "Majid", "given": "Aneela", "initials": "A"}, {"family": "Smedby", "given": "Karin E", "initials": "KE"}, {"family": "Lan", "given": "Qing", "initials": "Q"}, {"family": "Dearden", "given": "Claire", "initials": "C"}, {"family": "Brooks-Wilson", "given": "Angela R", "initials": "AR"}, {"family": "Hall", "given": "Andrew G", "initials": "AG"}, {"family": "Purdue", "given": "Mark P", "initials": "MP"}, {"family": "Mainou-Fowler", "given": "Tryfonia", "initials": "T"}, {"family": "Vajdic", "given": "Claire M", "initials": "CM", "orcid": "0000-0002-3612-8298", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc3e3af04c8a42d18d40304f2688c9f8.json"}}, {"family": "Jackson", "given": "Graham H", "initials": "GH"}, {"family": "Cocco", "given": "Pierluigi", "initials": "P"}, {"family": "Marr", "given": "Helen", "initials": "H"}, {"family": "Zhang", "given": "Yawei", "initials": "Y"}, {"family": "Zheng", "given": "Tongzhang", "initials": "T"}, {"family": "Giles", "given": "Graham G", "initials": "GG"}, {"family": "Lawrence", "given": "Charles", "initials": "C"}, {"family": "Call", "given": "Timothy G", "initials": "TG"}, {"family": "Liebow", "given": "Mark", "initials": "M"}, {"family": "Melbye", "given": "Mads", "initials": "M"}, {"family": "Glimelius", "given": "Bengt", "initials": "B"}, {"family": "Mansouri", "given": "Larry", "initials": "L"}, {"family": "Glenn", "given": "Martha", "initials": "M"}, {"family": "Curtin", "given": "Karen", "initials": "K"}, {"family": "Diver", "given": "W Ryan", "initials": "WR"}, {"family": "Link", "given": "Brian K", "initials": "BK"}, {"family": "Conde", "given": "Lucia", "initials": "L"}, {"family": "Bracci", "given": "Paige M", "initials": "PM"}, {"family": "Holly", "given": "Elizabeth A", "initials": "EA"}, {"family": "Jackson", "given": "Rebecca D", "initials": "RD"}, {"family": "Tinker", "given": "Lesley F", "initials": "LF"}, {"family": "Benavente", "given": "Yolanda", "initials": "Y"}, {"family": "Boffetta", "given": "Paolo", "initials": "P"}, {"family": "Brennan", "given": "Paul", "initials": "P"}, {"family": "Maynadie", "given": "Marc", "initials": "M"}, {"family": "McKay", "given": "James", "initials": "J"}, {"family": "Albanes", "given": "Demetrius", "initials": "D"}, {"family": "Weinstein", "given": "Stephanie", "initials": "S"}, {"family": "Wang", "given": "Zhaoming", "initials": "Z"}, {"family": "Caporaso", "given": "Neil E", "initials": "NE"}, {"family": "Morton", "given": "Lindsay M", "initials": "LM"}, {"family": "Severson", "given": "Richard K", "initials": "RK"}, {"family": "Riboli", "given": "Elio", "initials": "E"}, {"family": "Vineis", "given": "Paolo", "initials": "P"}, {"family": "Vermeulen", "given": "Roel C H", "initials": "RC"}, {"family": "Southey", "given": "Melissa C", "initials": "MC"}, {"family": "Milne", "given": "Roger L", "initials": "RL", "orcid": "0000-0001-5764-7268", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/412950bcee9d4f979f6a2cd4a1494862.json"}}, {"family": "Clavel", "given": "Jacqueline", "initials": "J"}, {"family": "Topka", "given": "Sabine", "initials": "S"}, {"family": "Spinelli", "given": "John J", "initials": "JJ"}, {"family": "Kraft", "given": "Peter", "initials": "P"}, {"family": "Ennas", "given": "Maria Grazia", "initials": "MG"}, {"family": "Summerfield", "given": "Geoffrey", "initials": "G"}, {"family": "Ferri", "given": "Giovanni M", "initials": "GM"}, {"family": "Harris", "given": "Robert J", "initials": "RJ"}, {"family": "Miligi", "given": "Lucia", "initials": "L"}, {"family": "Pettitt", "given": "Andrew R", "initials": "AR"}, {"family": "North", "given": "Kari E", "initials": "KE"}, {"family": "Allsup", "given": "David J", "initials": "DJ", "orcid": "0000-0001-6159-6109", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6828c5d394184614a53484294f16c63d.json"}}, {"family": "Fraumeni", "given": "Joseph F", "initials": "JF"}, {"family": "Bailey", "given": "James R", "initials": "JR"}, {"family": "Offit", "given": "Kenneth", "initials": "K"}, {"family": "Pratt", "given": "Guy", "initials": "G"}, {"family": "Hjalgrim", "given": "Henrik", "initials": "H"}, {"family": "Pepper", "given": "Chris", "initials": "C"}, {"family": "Chanock", "given": "Stephen J", "initials": "SJ"}, {"family": "Fegan", "given": "Chris", "initials": "C"}, {"family": "Rosenquist", "given": "Richard", "initials": "R"}, {"family": "de Sanjose", "given": "Silvia", "initials": "S"}, {"family": "Carracedo", "given": "Angel", "initials": "A"}, {"family": "Dyer", "given": "Martin J S", "initials": "MJ"}, {"family": "Catovsky", "given": "Daniel", "initials": "D"}, {"family": "Campo", "given": "Elias", "initials": "E", "orcid": "0000-0001-9850-9793", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/027ab2ad72e7442da10e441a24100503.json"}}, {"family": "Cerhan", "given": "James R", "initials": "JR"}, {"family": "Allan", "given": "James M", "initials": "JM"}, {"family": "Rothman", "given": "Nathanial", "initials": "N"}, {"family": "Houlston", "given": "Richard", "initials": "R"}, {"family": "Slager", "given": "Susan", "initials": "S"}], "type": "journal article", "published": "2017-02-06", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "8", "issue": null, "pages": "14175", "issn-l": "2041-1723"}, "abstract": "Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 \u00d7 10-13), 1q42.13 (rs41271473, P=1.06 \u00d7 10-10), 4q24 (rs71597109, P=1.37 \u00d7 10-10), 4q35.1 (rs57214277, P=3.69 \u00d7 10-8), 6p21.31 (rs3800461, P=1.97 \u00d7 10-8), 11q23.2 (rs61904987, P=2.64 \u00d7 10-11), 18q21.1 (rs1036935, P=3.27 \u00d7 10-8), 19p13.3 (rs7254272, P=4.67 \u00d7 10-8) and 22q13.33 (rs140522, P=2.70 \u00d7 10-9). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response.", "doi": "10.1038/ncomms14175", "pmid": "28165464", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5303820"}, {"db": "pii", "key": "ncomms14175"}], "notes": [], "created": "2018-12-05T11:27:15.547Z", "modified": "2026-09-23T07:41:41.443Z"}]}