{"entity": "researcher", "timestamp": "2026-09-28T13:20:17.053Z", "family": "Bihlmeyer", "given": "Nathan A", "initials": "NA", "orcid": "0000-0002-4415-7419", "affiliations": ["Predoctoral Training Program in Human Genetics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc2aae22d7d242d6934dd1fddfb7cfcd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc2aae22d7d242d6934dd1fddfb7cfcd"}}, "publications": [{"entity": "publication", "iuid": "f5ca9acda2394f8ca8555d14dcec24a4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f5ca9acda2394f8ca8555d14dcec24a4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f5ca9acda2394f8ca8555d14dcec24a4"}}, "title": "Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.", "authors": [{"family": "Christophersen", "given": "Ingrid E", "initials": "IE", "orcid": "0000-0002-6141-4712", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/66cf18798d82477a8771ce40cf067fed.json"}}, {"family": "Rienstra", "given": "Michiel", "initials": "M"}, {"family": "Roselli", "given": "Carolina", "initials": "C"}, {"family": "Yin", "given": "Xiaoyan", "initials": "X"}, {"family": "Geelhoed", "given": "Bastiaan", "initials": "B"}, {"family": "Barnard", "given": "John", "initials": "J", "orcid": "0000-0003-2403-8268", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c279a7a7e984d4491312768292ce611.json"}}, {"family": "Lin", "given": "Honghuang", "initials": "H", "orcid": "0000-0003-3043-3942", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fcff923f48845b88239000f20875e7c.json"}}, {"family": "Arking", "given": "Dan E", "initials": "DE"}, {"family": "Smith", "given": "Albert V", "initials": "AV", "orcid": "0000-0003-1942-5845", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51752e0d35a74befa66a65b95ceaad38.json"}}, {"family": "Albert", "given": "Christine M", "initials": "CM"}, {"family": "Chaffin", "given": "Mark", "initials": "M"}, {"family": "Tucker", "given": "Nathan R", "initials": "NR", "orcid": "0000-0002-5071-4218", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a084d5794114fcd924cb8962a6053f7.json"}}, {"family": "Li", "given": "Molong", "initials": "M"}, {"family": "Klarin", "given": "Derek", "initials": "D"}, {"family": "Bihlmeyer", "given": "Nathan A", "initials": "NA", "orcid": "0000-0002-4415-7419", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc2aae22d7d242d6934dd1fddfb7cfcd.json"}}, {"family": "Low", "given": "Siew-Kee", "initials": "SK"}, {"family": "Weeke", "given": "Peter E", "initials": "PE"}, {"family": "M\u00fcller-Nurasyid", "given": "Martina", "initials": "M"}, {"family": "Smith", "given": "J Gustav", "initials": "JG"}, {"family": "Brody", "given": "Jennifer A", "initials": "JA", "orcid": "0000-0001-8509-148X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f5e5e63068a4762ba2c4ca10f30aa78.json"}}, {"family": "Niemeijer", "given": "Maartje N", "initials": "MN"}, {"family": "D\u00f6rr", "given": "Marcus", "initials": "M"}, {"family": "Trompet", "given": "Stella", "initials": "S"}, {"family": "Huffman", "given": "Jennifer", "initials": "J", "orcid": "0000-0002-9672-2491", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/db300ba51fe547bbaa3c7dd94a48ae93.json"}}, {"family": "Gustafsson", "given": "Stefan", "initials": "S", "orcid": "0000-0001-5894-0351", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fedf8897d75744f5b17f7c91c892acbf.json"}}, {"family": "Schurmann", "given": "Claudia", "initials": "C"}, {"family": "Kleber", "given": "Marcus E", "initials": "ME", "orcid": "0000-0003-0663-7275", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22bc3077d1244542bcd6222f70dd7c96.json"}}, {"family": "Lyytik\u00e4inen", "given": "Leo-Pekka", "initials": "LP", "orcid": "0000-0002-7200-5455", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d541c99c43642538b7578fc4ff810ad.json"}}, {"family": "Sepp\u00e4l\u00e4", "given": "Ilkka", "initials": "I", "orcid": "0000-0002-5595-2573", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d0bf23c1b3b34d8789b46f2f425c37c9.json"}}, {"family": "Malik", "given": "Rainer", "initials": "R"}, {"family": "Horimoto", "given": "Andrea R V R", "initials": "ARVR"}, {"family": "Perez", "given": "Marco", "initials": "M"}, {"family": "Sinisalo", "given": "Juha", "initials": "J"}, {"family": "Aeschbacher", "given": "Stefanie", "initials": "S"}, {"family": "Th\u00e9riault", "given": "S\u00e9bastien", "initials": "S"}, {"family": "Yao", "given": "Jie", "initials": "J"}, {"family": "Radmanesh", "given": "Farid", "initials": "F"}, {"family": "Weiss", "given": "Stefan", "initials": "S", "orcid": "0000-0002-3553-4315", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ebf58f688caa49ab9e0a3e56349b1031.json"}}, {"family": "Teumer", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8309-094X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a40a959d1b8480cb8268e00f77a0449.json"}}, {"family": "Choi", "given": "Seung Hoan", "initials": "SH"}, {"family": "Weng", "given": "Lu-Chen", "initials": "LC"}, {"family": "Clauss", "given": "Sebastian", "initials": "S"}, {"family": "Deo", "given": "Rajat", "initials": "R"}, {"family": "Rader", "given": "Daniel J", "initials": "DJ"}, {"family": "Shah", "given": "Svati H", "initials": "SH"}, {"family": "Sun", "given": "Albert", "initials": "A"}, {"family": "Hopewell", "given": "Jemma C", "initials": "JC"}, {"family": "Debette", "given": "Stephanie", "initials": "S"}, {"family": "Chauhan", "given": "Ganesh", "initials": "G"}, {"family": "Yang", "given": "Qiong", "initials": "Q", "orcid": "0000-0002-3658-1375", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f83a12a89464005914934998b2b2ac3.json"}}, {"family": "Worrall", "given": "Bradford B", "initials": "BB"}, {"family": "Par\u00e9", "given": "Guillaume", "initials": "G"}, {"family": "Kamatani", "given": "Yoichiro", "initials": "Y"}, {"family": "Hagemeijer", "given": "Yanick P", "initials": "YP", "orcid": "0000-0001-6036-3741", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76b2c76095b149a89e349830770c5cc7.json"}}, {"family": "Verweij", "given": "Niek", "initials": "N"}, {"family": "Siland", "given": "Joylene E", "initials": "JE"}, {"family": "Kubo", "given": "Michiaki", "initials": "M"}, {"family": "Smith", "given": "Jonathan D", "initials": "JD", "orcid": "0000-0002-0415-386X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f08d6773c2134268bda75050772d397f.json"}}, {"family": "Van Wagoner", "given": "David R", "initials": "DR", "orcid": "0000-0001-8250-9828", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e6528e043f2445d1a87e83cf65906450.json"}}, {"family": "Bis", "given": "Joshua C", "initials": "JC"}, {"family": "Perz", "given": "Siegfried", "initials": "S"}, {"family": "Psaty", "given": "Bruce M", "initials": "BM"}, {"family": "Ridker", "given": "Paul M", "initials": "PM"}, {"family": "Magnani", "given": "Jared W", "initials": "JW"}, {"family": "Harris", "given": "Tamara B", "initials": "TB"}, {"family": "Launer", "given": "Lenore J", "initials": "LJ"}, {"family": "Shoemaker", "given": "M Benjamin", "initials": "MB"}, {"family": "Padmanabhan", "given": "Sandosh", "initials": "S"}, {"family": "Haessler", "given": "Jeffrey", "initials": "J"}, {"family": "Bartz", "given": "Traci M", "initials": "TM"}, {"family": "Waldenberger", "given": "Melanie", "initials": "M"}, {"family": "Lichtner", "given": "Peter", "initials": "P"}, {"family": "Arendt", "given": "Marina", "initials": "M"}, {"family": "Krieger", "given": "Jose E", "initials": "JE", "orcid": "0000-0001-5464-1792", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/15968b7f70c1488983df28fbd4942c2a.json"}}, {"family": "K\u00e4h\u00f6nen", "given": "Mika", "initials": "M"}, {"family": "Risch", "given": "Lorenz", "initials": "L"}, {"family": "Mansur", "given": "Alfredo J", "initials": "AJ"}, {"family": "Peters", "given": "Annette", "initials": "A"}, {"family": "Smith", "given": "Blair H", "initials": "BH", "orcid": "0000-0002-5362-9430", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f30912f5a8e443eac572814f3990d7f.json"}}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Scott", "given": "Stuart A", "initials": "SA", "orcid": "0000-0001-5720-1864", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/996702411c224c58a0f162518fecf580.json"}}, {"family": "Lu", "given": "Yingchang", "initials": "Y"}, {"family": "Bottinger", "given": "Erwin B", "initials": "EB"}, {"family": "Hernesniemi", "given": "Jussi", "initials": "J"}, {"family": "Lindgren", "given": "Cecilia M", "initials": "CM"}, {"family": "Wong", "given": "Jorge A", "initials": "JA"}, {"family": "Huang", "given": "Jie", "initials": "J"}, {"family": "Eskola", "given": "Markku", "initials": "M"}, {"family": "Morris", "given": "Andrew P", "initials": "AP"}, {"family": "Ford", "given": "Ian", "initials": "I"}, {"family": "Reiner", "given": "Alex P", "initials": "AP"}, {"family": "Delgado", "given": "Graciela", "initials": "G"}, {"family": "Chen", "given": "Lin Y", "initials": "LY"}, {"family": "Chen", "given": "Yii-Der Ida", "initials": "YI"}, {"family": "Sandhu", "given": "Roopinder K", "initials": "RK"}, {"family": "Li", "given": "Man", "initials": "M", "orcid": "0000-0002-3839-0281", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5436bf44eb30448d8ff5b2d9216500f5.json"}}, {"family": "Boerwinkle", "given": "Eric", "initials": "E"}, {"family": "Eisele", "given": "Lewin", "initials": "L"}, {"family": "Lannfelt", "given": "Lars", "initials": "L"}, {"family": "Rost", "given": "Natalia", "initials": "N"}, {"family": "Anderson", "given": "Christopher D", "initials": "CD"}, {"family": "Taylor", "given": "Kent D", "initials": "KD"}, {"family": "Campbell", "given": "Archie", "initials": "A", "orcid": "0000-0003-0198-5078", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0727bde0027c4a8a9d2737bb486f1bad.json"}}, {"family": "Magnusson", "given": "Patrik K", "initials": "PK"}, {"family": "Porteous", "given": "David", "initials": "D"}, {"family": "Hocking", "given": "Lynne J", "initials": "LJ"}, {"family": "Vlachopoulou", "given": "Efthymia", "initials": "E"}, {"family": "Pedersen", "given": "Nancy L", "initials": "NL"}, {"family": "Nikus", "given": "Kjell", "initials": "K"}, {"family": "Orho-Melander", "given": "Marju", "initials": "M"}, {"family": "Hamsten", "given": "Anders", "initials": "A"}, {"family": "Heeringa", "given": "Jan", "initials": "J"}, {"family": "Denny", "given": "Joshua C", "initials": "JC"}, {"family": "Kriebel", "given": "Jennifer", "initials": "J", "orcid": "0000-0003-4270-018X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7f77841a88d74185a43c7d5826062d7b.json"}}, {"family": "Darbar", "given": "Dawood", "initials": "D"}, {"family": "Newton-Cheh", "given": "Christopher", "initials": "C"}, {"family": "Shaffer", "given": "Christian", "initials": "C"}, {"family": "Macfarlane", "given": "Peter W", "initials": "PW"}, {"family": "Heilmann-Heimbach", "given": "Stefanie", "initials": "S"}, {"family": "Almgren", "given": "Peter", "initials": "P"}, {"family": "Huang", "given": "Paul L", "initials": "PL"}, {"family": "Sotoodehnia", "given": "Nona", "initials": "N"}, {"family": "Soliman", "given": "Elsayed Z", "initials": "EZ", "orcid": "0000-0001-5632-8150", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4d53591cd5a46cab26b9e1dd2ce46c2.json"}}, {"family": "Uitterlinden", "given": "Andre G", "initials": "AG"}, {"family": "Hofman", "given": "Albert", "initials": "A"}, {"family": "Franco", "given": "Oscar H", "initials": "OH"}, {"family": "V\u00f6lker", "given": "Uwe", "initials": "U"}, {"family": "J\u00f6ckel", "given": "Karl-Heinz", "initials": "KH"}, {"family": "Sinner", "given": "Moritz F", "initials": "MF"}, {"family": "Lin", "given": "Henry J", "initials": "HJ"}, {"family": "Guo", "given": "Xiuqing", "initials": "X"}, {"family": "METASTROKE Consortium of the ISGC", "given": "", "initials": ""}, {"family": "Neurology Working Group of the CHARGE Consortium", "given": "", "initials": ""}, {"family": "Dichgans", "given": "Martin", "initials": "M"}, {"family": "Ingelsson", "given": "Erik", "initials": "E"}, {"family": "Kooperberg", "given": "Charles", "initials": "C"}, {"family": "Melander", "given": "Olle", "initials": "O"}, {"family": "Loos", "given": "Ruth J F", "initials": "RJF"}, {"family": "Laurikka", "given": "Jari", "initials": "J"}, {"family": "Conen", "given": "David", "initials": "D"}, {"family": "Rosand", "given": "Jonathan", "initials": "J"}, {"family": "van der Harst", "given": "Pim", "initials": "P"}, {"family": "Lokki", "given": "Marja-Liisa", "initials": "ML"}, {"family": "Kathiresan", "given": "Sekar", "initials": "S"}, {"family": "Pereira", "given": "Alexandre", "initials": "A"}, {"family": "Jukema", "given": "J Wouter", "initials": "JW", "orcid": "0000-0002-3246-8359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51be7e89ccfd4bbe93b216028c57a376.json"}}, {"family": "Hayward", "given": "Caroline", "initials": "C"}, {"family": "Rotter", "given": "Jerome I", "initials": "JI"}, {"family": "M\u00e4rz", "given": "Winfried", "initials": "W"}, {"family": "Lehtim\u00e4ki", "given": "Terho", "initials": "T"}, {"family": "Stricker", "given": "Bruno H", "initials": "BH"}, {"family": "Chung", "given": "Mina K", "initials": "MK"}, {"family": "Felix", "given": "Stephan B", "initials": "SB"}, {"family": "Gudnason", "given": "Vilmundur", "initials": "V"}, {"family": "Alonso", "given": "Alvaro", "initials": "A"}, {"family": "Roden", "given": "Dan M", "initials": "DM"}, {"family": "K\u00e4\u00e4b", "given": "Stefan", "initials": "S"}, {"family": "Chasman", "given": "Daniel I", "initials": "DI"}, {"family": "Heckbert", "given": "Susan R", "initials": "SR"}, {"family": "Benjamin", "given": "Emelia J", "initials": "EJ", "orcid": "0000-0003-4076-2336", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/89bc31f5dd38446b9ffb36e68201e2da.json"}}, {"family": "Tanaka", "given": "Toshihiro", "initials": "T", "orcid": "0000-0001-6201-9784", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76061df47a364337a534ddafa3176e79.json"}}, {"family": "Lunetta", "given": "Kathryn L", "initials": "KL"}, {"family": "Lubitz", "given": "Steven A", "initials": "SA"}, {"family": "Ellinor", "given": "Patrick T", "initials": "PT", "orcid": "0000-0002-2067-0533", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fd1830794e884e6e849fd4f7645c9b61.json"}}, {"family": "AFGen Consortium", "given": "", "initials": ""}], "type": "journal article", "published": "2017-06-00", "journal": {"title": "Nat. Genet.", "issn": "1546-1718", "volume": "49", "issue": "6", "pages": "946-952", "issn-l": "1061-4036"}, "abstract": "Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death. Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups. To further define the genetic basis of atrial fibrillation, we performed large-scale, trans-ancestry meta-analyses of common and rare variant association studies. The genome-wide association studies (GWAS) included 17,931 individuals with atrial fibrillation and 115,142 referents; the exome-wide association studies (ExWAS) and rare variant association studies (RVAS) involved 22,346 cases and 132,086 referents. We identified 12 new genetic loci that exceeded genome-wide significance, implicating genes involved in cardiac electrical and structural remodeling. Our results nearly double the number of known genetic loci for atrial fibrillation, provide insights into the molecular basis of atrial fibrillation, and may facilitate the identification of new potential targets for drug discovery.", "doi": "10.1038/ng.3843", "pmid": "28416818", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS901319"}, {"db": "pmc", "key": "PMC5585859"}, {"db": "pii", "key": "ng.3843"}], "notes": [], "created": "2018-12-05T09:14:27.701Z", "modified": "2026-09-23T06:35:46.851Z"}]}